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Proteomics & Metabolomics

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Five noncovalent peptidic ligands show different affinity rankings in solution and gas phase

Poster

Published: October 23, 2009

| Last Updated: October 23, 2009

Five noncovalent peptidic ligands show different affinity rankings in solution and gas phase content piece image

Stability of noncovalent complexes of VEGF protein with 5 peptidic ligands is studied. Experiments were conducted in solution (NMR CSP, ITC) and in gas phase (CID TOF MS). Each ligand differs from others in chirality of one amino acid. It was shown, that trend of stability of the studied noncovalent complexes is reversed in the gas phase relatively to the solution. An explanation of this behavior is presented.