Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?
Poster May 22, 2018
Moon A, Haan N, Brydges N, Thomas K, Hall J
Early life stress (ELS) is highly associated with development of psychopathology and mood disorders in adulthood.
Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders.
This poster assesses the expression of Cacna1c following prepubertal stress.
P450 Induction in Cryopreserved Hepatocytes from PXR and CAR Nuclear Receptor Knock-out RatsPoster
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that regulate the expression of phase I (cytochrome P450s), phase II metabolizing enzymes and transporter genes in response to xenobiotics, including prescription drugs.READ MORE
Depression, Anxiety and Apathy in Young-Onset and Atypical Dementia: A systematic reviewPoster
This study aims to examine the body of empirical studies investigating the prevalence of depression, anxiety, and apathy in atypical and young-onset dementia.
Regulatory T-Cells (Tregs) Within Bone Marrow-Derived Stem Cells (BMSCs) Actively Confer Immunomodulatory and Neuroprotective Effects Against StrokePoster
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE