Role of TDP-43 in activation of the brain inflammatory response
Poster Feb 13, 2017
Frank Zamudio, Corbin Rodier, Anjanet Loon, Khawla Benyamine, Carlos Osorno, Shayna Smeltzer, and Maj-Linda Selenica
TDP-43 is associated with fronto-temporal lobar dementia (FTLD) and some cases of Alzheimer’s disease. Previous studies have found a role for TDP-43 in regulation of inflammatory markers such as IL-6, but the effect of increased TDP-43 expression on inflammation has not been studied. In order to fill these gaps, we induced peripheral inflammation in WT and TDP-43 overexpressing mice and began profiling changes in inflammatory cytokines, receptors, and kinases, in addition to changes in behavior.
Proteomics and Substrate Based MS Imaging of Xenobiotic Metabolising Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent ModelPoster
Untargeted proteomics analysis showed that human skin and a commercially available living skin equivalent model exhibit a similar distribution of xenobiotic metabolising enzymes. A new technique, substrate based mass spectrometry imaging (SB-MSI) was developed during this study.READ MORE
www.thebraindomain.org: Science Writing for Public EngagementPoster
The Brain Domain is a blog and article focused public engagement website, geared towards helping young neuroscientists improve their skills in science writing and communication.READ MORE
MEG Resting State Functional Connectivity and Network Topology in Dyslexia Related GenotypePoster
Studying resting state neuro-functional interactions and their network distribution may tell us more about differences in typical and a typical brain development.