Role of TDP-43 in activation of the brain inflammatory response
Poster Feb 13, 2017
Frank Zamudio, Corbin Rodier, Anjanet Loon, Khawla Benyamine, Carlos Osorno, Shayna Smeltzer, and Maj-Linda Selenica
TDP-43 is associated with fronto-temporal lobar dementia (FTLD) and some cases of Alzheimer’s disease. Previous studies have found a role for TDP-43 in regulation of inflammatory markers such as IL-6, but the effect of increased TDP-43 expression on inflammation has not been studied. In order to fill these gaps, we induced peripheral inflammation in WT and TDP-43 overexpressing mice and began profiling changes in inflammatory cytokines, receptors, and kinases, in addition to changes in behavior.
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE