Role of TDP-43 in activation of the brain inflammatory response
Poster Feb 13, 2017
Frank Zamudio, Corbin Rodier, Anjanet Loon, Khawla Benyamine, Carlos Osorno, Shayna Smeltzer, and Maj-Linda Selenica
TDP-43 is associated with fronto-temporal lobar dementia (FTLD) and some cases of Alzheimer’s disease. Previous studies have found a role for TDP-43 in regulation of inflammatory markers such as IL-6, but the effect of increased TDP-43 expression on inflammation has not been studied. In order to fill these gaps, we induced peripheral inflammation in WT and TDP-43 overexpressing mice and began profiling changes in inflammatory cytokines, receptors, and kinases, in addition to changes in behavior.
Extracorporeal shockwave therapy accelerates motor axon regeneration despite a phenotypically mismatched environmentPoster
A femoral nerve defect model was adapted for the evaluation of proregenerative effects of extracorporeal shockwave therapy (ESWT). Functional evaluation, histology and qRT-PCR data show differences between sensory and motor-derived nerve transplants and a pro-regenerative effect of ESWT. These data provide evidence for the clinical application of ESWT after autologous nerve transplantation as a novel non-invasive method.READ MORE
Age-related Histological Changes in Subjects with Nasal Polyps and Healthy ControlsPoster
Significant histological differences in subjects with NP and healthy controls exist among different age groups.READ MORE