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Spontaneous Calcium Oscillations of Networked Human iPSC Derived Cortical Neurons as a Sensitive Model for Neurotoxicity Screening

Poster   May 31, 2019

 
Spontaneous Calcium Oscillations of Networked Human iPSC Derived Cortical Neurons as a Sensitive Model for Neurotoxicity Screening
 
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Kurt Laha 1 , Zhong Wei Du 1

 
 

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

 
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To develop a neuronal 3D spheroid culture system, we tested iPSC-derived human motor neurons and cortical glutamatergic neurons using the S-BIO PrimeSurface Ultra Low Attachment Micoplates.

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Identification of New Hit Compounds Using a High-Throughput Phenotypic Screen with SMA Patient iPSC-Derived Motor Neurons

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Spinal muscular atrophy (SMA) is an inheritable cause of infant mortality that is characterized by the loss of lower motor neurons and skeletal muscle atrophy. The degeneration of motor neurons is caused by insufficient levels of survival motor neuron (SMN) protein, which is encoded by two nearly identical genes SMN1 and SMN2. Most cases of SMA harbour homozygous deletions of the SMN1 gene and retain at least one copy of SMN2.

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Optimized Conditions for MEA Assay with Human iPSC-Derived Spinal Motor Neurons, Glutamatergic Neurons and Mixed Cortical Neurons

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In order to generate a robust protocol for MEA recording on hiPSC- derived neurons, we evaluated several conditions, which could affect culture performance (1.neuron seeding density; 2.seeding medium; 3.astrocyt eco-culture). These conditions were evaluated with BrainXell’s hiPSC-derived spinal motor neurons, cortical glutamatergic neurons and mixed cortical neurons.

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