Aarhus University Speeds Up Target Discovery and Verification
These mass spectrometry platforms allow targeted quantitative and rapid qualitative analyses of proteins and peptides that may be associated with human conditions, such as malignant cancers.
The protein chemistry laboratory, led by Professor Jan J. Enghild (www.enghild-lab.dk), has previously been involved in different biomarker identification projects. The researchers hope to verify the findings from some of these projects and to identify novel biomarkers for early stage development of lung, ovary, and prostate cancers, in collaboration with the Aarhus University Hospital. The new studies will use the outstanding speed and sensitivity of the TripleTOF™ 5600 System to reveal novel protein targets in different bodily fluids, for subsequent targeted analysis with the QTRAP® 5500 integrated triple quadrupole/linear accelerator trap.
The Enghild laboratory is engaged in many diverse collaborative projects, such as the characterization of protein aggregation in corneal dystrophies, investigations of human metabolic responses to fatty acids, and isolation of novel proteolytic enzymes in exotic creatures such as tarantula spiders.
“We were looking for an instrument with high resolution, mass accuracy and sensitivity for our qualitative needs,” said Kristian W. Sangaard, Senior Advisor at the Laboratory, Aarhus University. “By combining the TripleTOF System with the QTRAP 5500 System, we now have a fast, sensitive and robust platform with shared front-end technology and a very high analytical capacity that can be taken all the way from explorative discovery proteomics right up to targeted proteomics analysis.”
“The exceptional speed, capabilities and sensitivity of our TripleTOF 5600 and QTRAP 5500 Systems are essential for today’s proteomics laboratories to analyse very low level peptides and proteins,” said Anthony Sullivan, European Regional Business Development Specialist, AB SCIEX. “The instruments’ enhanced accuracy and throughput will allow scientists to push new limits of discovery and possibilities in a broad range of applications.”