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Applied Biomics, Inc. Adds Global Protein PTM Profiling Service

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The company announce the addition of the Global Protein Post-Translational Modification (PTM) Profiling service to its proteomics line. The protein PTMs play a critical role in a wide range of cellular and pathogenesis processes.

The procedure of Protein PTM Profiling involves 2D DIGE followed by quantitative single- or double-color fluorescent 2D Western blot. Proteins with Post-Translational Modifications (PTMs) can be presented in high-resolution 2D images. In addition, the PTM levels in difference samples can be quantified and compared. This service targets the following common Post-Translational Modifications (PTMs):

- Phosphorylation (pSer, pThr, pTyr) - Ubiquitination - Acetylated-Lysine - Tyrosine sulfation - Methyl-Arginine - Nitrotyrosine - Biotinalytion.

The newly added Global Protein PTM Profiling benefits researches in these areas:

1) Identify novel proteins that are post-translationally modified

2) Confirm a specific protein of interest that is post-translationally modified

3) Quantify levels in post-translational modifications among different samples

4) In combination with 2D-DIGE, determine whether differentially expressed protein spots are also post-translationally modified

5) In combination with Mass Spectrometry, determine the site of post-translational modifications