Bruker Introduces AccuScreen™ Accurate Mass Ion Chromatograms
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Bruker Daltonics has announced the AccuScreen™ method for high resolution, accurate mass extracted ion chromatograms on its micrOTOF™ ESI-TOF and micrOTOF-Q™ ESI-Q-q-TOF mass spectrometers at Pittcon 2006.
AccuScreen is designed to yield LC-MS and LC-MS/MS performance in target compound analyses in complex matrices, such as body fluids, complex small molecule libraries, quantitative proteomics, etc.
Applications of AccuScreen include ADME/tox studies in drug development, biomarker analysis, quantitative proteomics and other areas such as forensic high-resolution screening for drugs of abuse, poisons or toxic chemicals.
Bruker claims that, the AccuScreen accurate mass ion chromatograms (AMICs) dramatically reduce chemical background interference and improve specificity over normal +/- 0.5 Dalton (Da) extracted ion chromatograms whether the assay is quantitative or qualitative in nature.
The AccuScreen AMICs can be generated with a tolerance down to +/- 0.002Da, a capability enabled by the design of the micrOTOF-series with external calibration of 5ppm, and high resolution of 10,000 (FWHM) over the entire MS/(MS) mass range run and across the full dynamic range of a typical HPLC run.
The bench-top micrOTOF-series features sensitivity and stability, as well as mass accuracy of 3 ppm with internal calibration, and mass resolution of 15,000 (FWHM).
Dr. Ian Sanders, Vice President of Bruker Daltonics, explained, "In contrast to traditional target-specific triple-quadrupole mass spectrometry assays, AccuScreen enables screening approaches without the need to know the target compounds already before the analysis."
"In particular, new targets can be screened for and can be identified based of the micrOTOF's unique sigmaFit™ molecular formula determination even months after the analysis."
"While in triple-quad MS/MS target screening most of the available molecular information simply cannot be measured and is discarded, for AccuScreen using high-resolution AMICS the number of screening targets is virtually unlimited."
Bruker Daltonics will exhibit at booth #3155 at Pittcon 2006.
