rPeptide Introduces Amyloid Precursor Proteins

rPeptide, a biotechnology company providing research products for Alzheimer's disease and Parkinson's disease research has announced the release of new amyloid precursor proteins for drug discovery research.

Amyloid Precursor Protein, CTF fragments.

(i) Beta-Amyloid Precursor Protein, CTF-31

MW: 3717.1 Da

H-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH; APP 740-770

Description: Lyophilized solid; TFA salt; Purity > 95% packed under inert gas; hygroscopic; light sensitive. A 31-amino acid peptide, results from the proteolytic cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Asp739-Ala740 by caspases. Reported to induce apoptosis and may be involved in the neuronal death associated with Alzheimer’s disease, either via amplifying caspase activation or by the selective increase in Abeta 42 production.

(ii) Beta-Amyloid Precursor Protein, CTF-50

MW: 5910.7 Da

H-Val-Met-Leu-Lys-Lys-Lys-Gln-Tyr-Thr-Ser-Ile-His-His-Gly-Val-Val-Glu-Val-Asp-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH; APP 721-770

Description: Lyophilized solid; TFA salt; Purity > 95% packed under inert gas; hygroscopic; light sensitive. A 50-amino acid peptide, results from the ?-secretase cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Leu720-Val721. May also serve as one of the precursors for the generation of the toxic C31 fragment of APP (Cat. No. A-1201)

(iii) Beta-Amyloid Precursor Protein, CTF-57

MW: 6650.7 Da

H-Thr-Val-Ile-Val-Ile-Thr-Leu-Val-Met-Leu-Lys-Lys-Lys-Gln-Tyr-Thr-Ser-Ile-His-His-Gly-Val-Val-Glu-Val-Asp-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH; APP 714-770

Description: Lyophilized solid; TFA salt; Purity > 95% packed under inert gas; hygroscopic; light sensitive. A 57-amino acid peptide, results from the ?-secretase cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Ala713-Thr714. Represents CTFg fragment naturally generated in conjunction with Abeta42. May also serve as one of the precursors for the generation of the toxic C31, fragment of APP (Cat. No. A-1201)