Signet Announces Availability of two Monoclonal Antibodies, L1 and PTEN

Signet Laboratories, Inc. has announced the availability of two monoclonal antibodies L1 clone 14.10 and PTEN clone 6H2.1

The mouse monoclonal anti-L1 clone 14.10 recognizes the L1 protein (CD171), a transmembrane protein that belongs to the immunoglobulin supergene family.

Data indicate that L1 may be overexpressed in a variety of carcinomas. Studies have implicated L1 as a marker of unfavorable prognosis in a variety of malignancies.

Clone 6H2.1 recognizes PTEN (phosphatase and tensin homolog), a tumor suppressor protein that is encoded by a gene located on chromosome 10. PTEN mutations have been observed in a wide range of cancers.

The addition of L1 and PTEN complements Signet's current product offerings for cancer research. Signet's product portfolio includes markers such as D2- 40, Cyclin D1, Cyclin E, HE4 and Hepsin.