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The New SCIEX Mass Spec: The ZenoTOF 7600 System

The New SCIEX Mass Spec: The ZenoTOF 7600 System

The Zeno revolution is now…
A new era in life science research has begun with the ZenoTOF 7600 system: This high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to transform compound ID in protein, metabolite, and lipid analysis. Unlock sensitivity gains that reveal new, rare, or even previously undetected information on an everyday basis. Uncover new perspectives for every molecule, in every experiment.

A new mindset in accurate mass LC-MS/MS technology
Driven by the power of Zeno trap coupled with EAD technology, this fragment-centric revolution unlocks sensitivity gains allowing you to uncover new information, for more certainty in your results, and to make better-informed decisions, faster.

 The ZenoTOF 7600 system unlocks unprecedented speed with scan rates up to 133Hz (133 MS/MS per second). This enables quantitative flexibility to match the throughput demands of translational proteomics. Higher throughput proteomics requires accurate, precise, and reproducible quantification of all analytes, at all concentrations.

Over 40% more proteins identified using Zeno MS/MS
Utilizing high throughput micro flow methodologies, the ZenoTOF 7600 system breaks through the 3,000 protein groups in 21 minutes for the first time. Unique Zeno trap pulsing provides significant gains in peptide and protein identifications for proteomics experiments. Up to ~ 45% improvements in the number of protein IDs and up to a 145% increase in the number of peptide IDs, compared to previous TripleTOF technologies.

Unparallel gains in compound ID confidence in metabolomics and  lipidomics
The ZenoTOF 7600 tackles the grand challenge of compound ID in metabolomics and lipidomics head-on by generating uniquely detailed MS/MS spectra via its novel EAD technology. EAD contains unique fragment ions with patterns and intensities that can be used for complete structure elucidation in a single injection. When combined with the Zeno trap, the sensitivity of electron-based fragmentation is greatly enhanced resulting in large MS/MS sensitivity gains.

The ZenoTOF 7600, will especially transform your lipidomics research by enabling you to achieve complete structure elucidation of lipids in a single experiment including fatty acid attachment points (regioisomerism), location of a double bond, and cis or trans configuration.
• Overcome QTOF MS/MS duty cycle deficiencies    
• >90% ions injected into the TOF
• Sensitivity gains of up to 5-20x with Zeno trap pulsing   
• Identify and quantify low abundance species
• Tunable fragmentation of all molecule types    
• Utilize controlled electron activated dissociation (EAD)
• MS/MS scan rates of up to 133Hz   
• Improved DDA and high resolution MRM (MRMRHR)


SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research.
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