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TripleTOF® 6600 LC-MS/ MS System with ZipChip

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TripleTOF® 6600 LC-MS/ MS System with ZipChip

There are many challenges when analysing charge variants of biotherapeutics, especially when traditional chromatography approaches require method development for each molecule. While capillary zone electrophoresis (CZE) is a gold standard method for rapid charge variant analysis, it can still be difficult to determine the identity of the separated species. In short, it is challenging to deploy a platform that both provides charge variant identification and is suitable for a release assay.

Until now.

The ZipChip system coupled with the TripleTOF® 6600 LC-MS/MS System work together to enable a complete solution for charge variant identification to inform charge variant release assay.

The ZipChip system allows for turnkey analysis of proteins with easy-to-use kits for a variety of protein workflows as well as dependable online quantification and identification of protein charge variants. It is also a platform assay that requires no method development across a very wide range of biotherapeutics.

High-resolution mass spectra from the TripleTOF 6600 System, when combined with the inline charge-based separation of the ZipChip system, provides unambiguous identification of the neutral, acidic and basic species.

The gold standard charge variant assay just went platinum. SCIEX offers a highly flexible and reliable solution to better meet the challenges of charge variant analysis with the ZipChip system coupled with the TripleTOF 6600 System.

Company Details
SCIEX
500 Old Connecticut Path
Framingham, MA 01701
USA
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