Advanced Cell Models – Webinars and Online Events

This webinar will examine the benefits of combining LOAC with in silico modeling to explore clinical PK predictions of specific reference drugs, including investigations into the intrinsic clearance determinations for high metabolically stable compounds and the quantitation of fractions metabolized by specific enzymes.

Human induced pluripotent stem cell (iPSC)-derived retinal organoids are an emerging tool for the study of retinal development, disease modeling and drug discovery.

In drug development, microphysiological systems (MPS) are utilized to develop in vitro biological models that can generate more physiologically- and human-relevant data.

Most in vitro, well-plate biological experiments require a media change every day or two, with cyclic variations in nutrient and metabolite concentrations leading to physiologically unrealistic gene expression and metabolism.

In this webinar, we will demonstrate how an advanced three-dimensional (3D) microfluidic model of non-alcoholic steatohepatitis (NASH) can be fine-tuned using exogenous stimuli to enhance key features such as fibrosis or inflammation.

Microphysiological Systems (MPS), also known as organ-on-a-chip, generate human-relevant 3D cell culture models whose phenotypes and functions mimic individual in vivo organs. When therapeutics are added, these models can generate results that translate into clinical outcomes more reliably than standard in vitro techniques.

Mucosal barriers are the gateways to all internal organs, serving to transport oxygen, nutrients, and waste and at the same time performing enormous feats of protection against infection and other hazardous insults. The explosion of interest in the human microbiome – especially but not only that in the gut – has driven new interest in building human mucosal barrier models.

Metastatic disease is the leading cause of mortality in patients with solid tumors. Despite decades of research, we only partially understand the underlying cellular and molecular mechanisms.

Current in vitro approaches for investigational toxicology, drug metabolism (DMPK) and safety are limited and are not fully representative of human response; therefore, drugs showing acceptable preclinical toxicity often fail in human clinical trials, and accurately predicting human drug exposure for new compounds is challenging and costly.

Microphysiological systems (MPS), or organ-on-chip (OOC) technologies, enable researchers to model human biology in the lab via 3D microtissue-based studies.