Cancer Immunology – News and Features

UCLA researchers developed a non-invasive imaging method using 89Zr-TLX250 to detect clear-cell renal cell carcinoma. This technique demonstrated high sensitivity (85.5%) and specificity (87.0%), effectively identifying cancer in small renal masses.

A new treatment has been proposed for immunotherapy-resistant brain metastases, with a biomarker identified that can predict cases in which it should be used.

An unexpected role of estrogen in fueling the growth of breast and other cancers has been discovered.

Researchers at the University of Geneva developed CAR T cells targeting the glioblastoma marker PTPRZ1, showing efficacy against tumors. These cells not only attack marked tumor cells but also eliminate others through a bystander effect.

A study shows that the CAR-T cells of long-term survivors of acute lymphoblastic leukemia exhibit a distinct type 2 immune response, linked to increased remission rates. A second study indicates that modifying IL-4 can enhance T cell metabolism.

A new mouse study has identified a promising drug combination for the treatment of muscle-invasive bladder cancer.

Immune cells' hybrid-like nature makes them promising candidates for developing new kinds of immunotherapies against diseases such as cancer.

Researchers used single-cell RNA sequencing in human datasets to understand more about differences in how male and female immune systems respond to tumors.

A study indicates that older cancer survivors face over double the rate of cardiovascular events, such as stroke and heart attack, compared to cancer-free individuals. Chemotherapy significantly contributes to this increased risk.

Researchers found that sphingolipids, rather than serving solely as energy sources, are critical for cancer cells to evade immune responses. Blocking sphingolipid production with existing FDA-approved drugs can enhance immune detection of tumors.