Gene and Cell Therapy – News and Features

Researchers have developed a new electrically active biomaterial that can be transplanted into the body to improve recovery following central nervous system injuries. The material acts as a scaffold that also provides electrical stimulation.

Researchers at Gladstone Institutes and SanBio demonstrated that a stem cell therapy, effective even a month after stroke, restored brain function in rats by reversing hyperexcitability and enhancing brain repair processes.

A new type of off-the-shelf cell-based immunotherapy shows promise for B-cell lymphomas, and could make make future cellular immunotherapies less expensive and more accessible.

UNC Lineberger researchers discovered a three-drug cocktail that enhances the production of T-memory stem cells (TSCMs) in CAR-T therapy, improving immune cell persistence and anti-tumor activity.

Researchers have developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.

A collaborative team has developed a new method to program molecular self-assembly predictably. Researchers created versatile materials like "Malteser molecules," which could serve as highly specific sensors or drug delivery agents.

A study explores the molecular dynamics of CD28.ζ-CAR and 4-1BB.ζ-CAR T cells at the immune synapse, where CAR T cells bind to cancer cells. CD28.ζ-CAR T cells act like sprinters, killing cancer cells quickly but briefly

The adaptive immune system is highly complex and specific. In this article we focus on T cells, and discuss their development, their different functions, and what happens when they don't function correctly.

The injection of heart muscle spheroids derived from hiPSCs can aid heart attack recovery in animal models.

ECRC researchers developed a CRISPR-based gene therapy targeting dysferlin mutations in muscular dystrophy. By editing and transplanting corrected muscle stem cells, they restored protein function and regrew muscle in preclinical models.