Light Microscopy – News and Features

Neurobiologists discovered that individual neurons can apply different plasticity rules in separate dendritic branches. This new understanding challenges prior assumptions of uniformity in synaptic changes and opens possibilities for improving AI.

Researchers at Tokyo University of Science have developed Chol-HDOs, which efficiently penetrate the brain, overcoming challenges associated with delivering gene-targeting drugs to brain tissue.

Contamination is one of the main roadblocks to successful cell culture. This article explores the different types of contamination, how to identify microbial contaminants in cell culture and best practices for removal and prevention.

Cornell researchers found that psilocybin’s therapeutic benefits depend on the pyramidal tract neurons and the serotonin 5-HT2A receptor in the medial frontal cortex. Targeting these mechanisms could allow psilocybin to treat depression.

For the first time, researchers have imaged living cells and capillaries inside whole organs, offering insights into how living cells behave and opportunities for diagnostics.

Around 50–90% of brain tumor patients that survive at least 6 months after radiotherapy experience some form of cognitive decline, such as memory loss. In a systematic review, we examined damage to the normal brain tissue after brain irradiation.

Researchers have developed a new method for environmental monitoring, based on near-infrared (NIR) light. The technique provides users with real-time spectral information from various materials and biological samples.

Scientists at HHMI’s Janelia Research Campus developed cycleHCR, an imaging tool using DNA barcodes to track RNA and protein molecules in 3D tissues. The technique enables deep tissue imaging of hundreds of molecular targets.

A new approach to monitoring molecular processes deep in tissues could accelerate personalized medicine, cancer diagnostics and disease detection.

An AI-enabled device could make flow cytometry affordable and accessible, reports a new study from Rice University.