Neurogenomics – News and Features

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Fat Cells Remember Obesity, Driving the Yo-Yo Effect
ETH Zurich researchers have identified an epigenetic memory in fat cells that drives the yo-yo effect after weight loss. Studies in mice and humans reveal that fat cells retain obesity markers, making weight regain easier.

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Cerebrospinal Fluid Study Unveils Potential Alzheimer’s Drug Targets
Using cerebrospinal fluid, researchers have identified proteins and genes linked to Alzheimer's progression that could form drug targets.

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Breast Cancer Model May Help Us Understand Why and Where It Spreads
A new model for studying breast cancer could help researchers better understand why and where it metastasizes.

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Key Pathway Linked to Early Neurodegeneration in ALS Uncovered
Researchers report that they have identified a key pathway that sets off neurodegeneration in the early stages of amyotrophic lateral sclerosis.

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Gene Mutation May Explain Rare Neurological Disorders
A new study links FLVCR1 mutations to a spectrum of neurodevelopmental disorders. Researchers found that these gene variants affect essential choline transport, resulting in symptoms like anemia and brain malformations.

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Understanding the Gut Microbiota’s Influence on Stress and the Brains Circadian System
Research from University College Cork shows that gut microbiota influences stress responses via circadian rhythms. Depleting gut bacteria alters stress hormone levels and disrupts gene expression in the brain.

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New Genes Associated With Disc Herniations
In a new study, numerous genomic regions potentially affecting the structure of the discs and inflammatory factors were found. The study found 41 novel regions of the genome that modify the disease risk for disc herniations.

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Researchers Uncover Proteins Linking Brain Connectivity and Function
A study reveals hundreds of proteins that explain differences in brain connectivity, linking molecular data with neuroimaging in aging individuals. This research enhances understanding of cognitive function.

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New Clusters of Cells Identified in the Human Amygdala
Scientists at UC Davis discovered new gene expression clusters in the amygdala of humans and non-human primates, enhancing understanding of emotional disorders. This research may open pathways for developing targeted therapies for anxiety.

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Childhood Attention Variability and Genetic Factors May Predict Psychosis Risk
Researchers looked at how the youths’ risk for psychotic-like experiences varied based on their attention span and genetic variants that may predispose them to different neuropsychiatric conditions.
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