Neurogenomics – News and Features

Researchers discovered that alcohol exposure prior to embryo implantation leads to significant molecular changes in the placenta, including altered gene expression and DNA methylation.

Researchers shed light on why only maternal DNA is inherited inside the mitochondria and why if paternal mitochondria slips into a developing embryo, it can lead to lasting neurological, behavioral and reproductive problems in adults.

A collaborative study between UK and Italian researchers investigates the biological mechanisms of major depressive disorder (MDD), focusing on the immune system's involvement. The research highlights gene expression profiles linked to inflammation.

Researchers at the University of Chicago found that the TET2 gene affects RNA modifications, influencing how DNA is packaged in cells. TET2 mutations may lead to cancer by disrupting this process, suggesting new targets for therapies.

In a preclinical model, researchers have discovered that two genetic variants that confer a high risk of AD together trigger a harmful inflammatory response in the brain's immune cells, particularly in females.

Researchers at the Johns Hopkins University School of Medicine have mapped variation in human stem cells that explains how cells of an individual may shape a unique “developmental dance”.

Research reveals significant differences in threat processing between male and female mice, despite similar behavioral responses. The study emphasizes the importance of including both sexes in neuroscience research.

Single-cell analysis offers a unique perspective of the genetic and molecular features of individual cells. In this article, two early adopters of single-cell analysis technologies highlight some of the latest advances and new applications.

This article examines how next-generation sequencing and state-of-the-art imaging technologies are being combined to characterize and map the spatial organization of cell types in tissues.

Researchers have discovered a mechanism behind dopamine dysregulation syndrome (DDS) in Parkinson’s patients treated with Levodopa. Their study found that Levodopa induces abnormal activation of dopamine D1 receptor-expressing neurons.