Neurogenomics – News and Features

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Mapping Development and Disease With Spatial Biology Technologies
This article examines how next-generation sequencing and state-of-the-art imaging technologies are being combined to characterize and map the spatial organization of cell types in tissues.

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A Parkinson’s Drug Can Cause Psychiatric Complications – Now Researchers Know Why
Researchers have discovered a mechanism behind dopamine dysregulation syndrome (DDS) in Parkinson’s patients treated with Levodopa. Their study found that Levodopa induces abnormal activation of dopamine D1 receptor-expressing neurons.

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Reprogramming Astrocytes Into Brain Stem Cells
Researchers showed that experimentally induced lack of blood flow in the brain epigenetically reprograms astrocytes into brain stem cells, which in turn can give rise to nerve progenitor cells.

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Queensland Scientists Identify New DNA Regulation Mechanism
University of Queensland researchers have identified two enzymes that regulate a chemical modification in mitochondrial DNA, preventing the accumulation and inheritance of disease-causing mutations.

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Study Examines Effect of Alzheimer's Drug on Tissue Samples from People with Down Syndrome
A study found that lecanemab effectively targets amyloid plaques in brain tissue of people with Down syndrome, who are prone to early Alzheimer's. While promising, the drug also binds to brain blood vessels, raising safety concerns.

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Single Gene Knock-Out Causes Mice To Display Hallmark Behaviors of Autism
Knocking out a gene linked to brain circuitry leads to several hallmark behaviors of autism, a new study has found.

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How Microglial Phagosomes Shape Brain Health and Disease
Researchers have developed a method to isolate and analyze microglia phagosomes in a rapid, gentle, and unbiased fashion. They also share new insights regarding synaptic pruning and generation of NAD+, a broadly used molecule in the brain, by microglia.

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Zebrafish Reveal Neuron Protection as Critical Step in Spinal Cord Regeneration
Researchers at Washington University School of Medicine in St. Louis describe the dramatic changes within nerve cells that make regeneration possible. Such findings could inspire the development of new therapies for spinal cord injuries in people.

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Biologists Map DNA of Lyme Disease Bacteria, Unlocking Potential for Tailored Therapies
A team led by CUNY Graduate Center biologists has produced a genetic analysis of Lyme disease bacteria that may pave the way for improved diagnosis, treatment, and prevention of the tick-borne ailment.

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Re-Engineered Parasite Delivers Drugs to the Human Brain
Researchers have reengineered Toxoplasma gondii, the 'cat parasite,' transforming it from a feared threat into a groundbreaking tool for delivering drugs directly to the brain.
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