Neurogenomics – News and Features

Researchers looked at how the youths’ risk for psychotic-like experiences varied based on their attention span and genetic variants that may predispose them to different neuropsychiatric conditions.

A new mouse study shows how a new tool can deliver genetic material to edit faulty genes in developing fetal brain cells.

A study from Scripps Research utilizes patient-derived mini-brains to investigate how MEF2C mutations cause autism spectrum disorder (ASD) by disrupting brain cell balance. The research identified a potential treatment.

Researchers from the ENIGMA consortium have identified 254 genetic variants affecting key deep brain structures involved in memory, movement, and emotion regulation. The study links these variants to increased risks for Parkinson's disease and ADHD.

Research from CU Boulder highlights the critical role of paternal mitochondria elimination (PME) in embryo development. Delaying PME results in decreased ATP production, leading to embryonic lethality and physiological defects.

Colossal reports significant advancements in thylacine de-extinction efforts, including the generation of the highest quality ancient genome and record-breaking multiplex genome editing.

A study has unveiled the role of CDK5RAP2 in activating the γ-tubulin ring complex (γTuRC), a vital component for microtubule formation in cells. By using cryo-electron microscopy, the team demonstrated how CDK5RAP2 binds to γTuRC.

An innovative genetic treatment for Gaucher disease has shown promise in mouse models, increasing lifespan and preserving motor function.

The researchers noticed that, compared to the control group, the mice given the oil showed significant improvement in learning and spatial memory.

Researchers have created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models accurately replicate human brain development.