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Single-Cell Analysis – News and Features

3D illustration of a cell showing the cell membrane and nucleus of the cell
Article

Cell Painting in Drug Discovery: A Conversation With Assay Pioneer Anne Carpenter

Technology Networks caught up with Dr. Anne Carpenter at ELRIG Drug Discovery 2024 to learn more about the Cell Painting assay and its impact on the pharmaceutical industry.
Cancer cells.
News

Origin of Deadly Ovarian Cancer Identified

Study reveals that high-grade serous carcinoma, the most aggressive form of ovarian cancer, originates from pre-ciliated tubal epithelial cells in the fallopian tube. This research provides insights into potential diagnostic and therapeutic targets.
Cell segmentation stain of human skin.
News

Researchers Create “Skin in a Dish” To Study How Skin Forms

A study reveals a detailed atlas of prenatal human skin, uncovering how hair follicles form and the role of immune cells in scarless healing. This research could enhance regenerative medicine approaches.
News

Mini Brains Reveal Mechanisms Behind Lewy Body Dementia

Scientists created mini-brain models from LBD patients' stem cells, mimicking key disease features. Using these models, they screened nearly 1,300 FDA-approved drugs and identified four potential compounds to inhibit alpha-synuclein buildup.
Iridescent T cells
News

Early Indicators of Multiple Sclerosis: Evidence From Monozygotic Twin Studies

In a study of identical twins, researchers have shown that a type of immune cell, CD8-positive T cells, plays a role in the early stages of the disease.
Letters representing DNA bases over a screen.
News

Risk of Private Single-Cell Data Leakage Quantified

Single-cell RNA-seq datasets could lead to privacy violations through "linking attacks," where hackers can identify individuals' genetic and phenotypic information. This study highlights the need for stricter consent policies.
A graphic of proteins within a cell.
News

Fixing the Huge Leak at the Ion Source in Mass Spec

Brown University scientists present a new mass spectrometry technology that overcomes a major limitation of electrospray ionization (ESI) – sample loss.
Cancer cells multiplying
News

Sex-Based Differences Identified in Immune Responses Against Tumors

Researchers used single-cell RNA sequencing in human datasets to understand more about differences in how male and female immune systems respond to tumors.
Floating cells on a pink background.
Article

Decoding Living Systems One Cell at a Time

Single-cell analysis offers a unique perspective of the genetic and molecular features of individual cells. In this article, two early adopters of single-cell analysis technologies highlight some of the latest advances and new applications.
Human form made from white dots of varying sizes on a pink/purple background.
Article

Mapping Development and Disease With Spatial Biology Technologies

This article examines how next-generation sequencing and state-of-the-art imaging technologies are being combined to characterize and map the spatial organization of cell types in tissues.
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