Single-Cell Analysis – News and Features
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Cell Painting in Drug Discovery: A Conversation With Assay Pioneer Anne Carpenter
Technology Networks caught up with Dr. Anne Carpenter at ELRIG Drug Discovery 2024 to learn more about the Cell Painting assay and its impact on the pharmaceutical industry.
News
Origin of Deadly Ovarian Cancer Identified
Study reveals that high-grade serous carcinoma, the most aggressive form of ovarian cancer, originates from pre-ciliated tubal epithelial cells in the fallopian tube. This research provides insights into potential diagnostic and therapeutic targets.
News
Researchers Create “Skin in a Dish” To Study How Skin Forms
A study reveals a detailed atlas of prenatal human skin, uncovering how hair follicles form and the role of immune cells in scarless healing. This research could enhance regenerative medicine approaches.
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Mini Brains Reveal Mechanisms Behind Lewy Body Dementia
Scientists created mini-brain models from LBD patients' stem cells, mimicking key disease features. Using these models, they screened nearly 1,300 FDA-approved drugs and identified four potential compounds to inhibit alpha-synuclein buildup.
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Early Indicators of Multiple Sclerosis: Evidence From Monozygotic Twin Studies
In a study of identical twins, researchers have shown that a type of immune cell, CD8-positive T cells, plays a role in the early stages of the disease.
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Risk of Private Single-Cell Data Leakage Quantified
Single-cell RNA-seq datasets could lead to privacy violations through "linking attacks," where hackers can identify individuals' genetic and phenotypic information. This study highlights the need for stricter consent policies.
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Fixing the Huge Leak at the Ion Source in Mass Spec
Brown University scientists present a new mass spectrometry technology that overcomes a major limitation of electrospray ionization (ESI) – sample loss.
News
Sex-Based Differences Identified in Immune Responses Against Tumors
Researchers used single-cell RNA sequencing in human datasets to understand more about differences in how male and female immune systems respond to tumors.
Article
Decoding Living Systems One Cell at a Time
Single-cell analysis offers a unique perspective of the genetic and molecular features of individual cells. In this article, two early adopters of single-cell analysis technologies highlight some of the latest advances and new applications.
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Mapping Development and Disease With Spatial Biology Technologies
This article examines how next-generation sequencing and state-of-the-art imaging technologies are being combined to characterize and map the spatial organization of cell types in tissues.
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