Single-Cell Analysis – News and Features

A study in mice showed that cells lose their identity and acquire adipogenic traits, as a mechanism underlying cellular aging.

Catching cells in the act of switching from 'pumping' to 'repair' mode with the use of single-cell RNA sequencing should raise alarms, researchers say.

To pick apart the differences between individual cells in complex multicellular organisms, we need to look at cells one-by-one. This article takes a look at how several scientists in North America are using single cell proteomics (SCP) technologies to discern disease pathogenesis and enhance directed stem-cell differentiation.

Research has yielded new insights into the environment surrounding different types of lung tumors, and described how these complex cell ecosystems may in turn ultimately affect response to treatment.

Basophils, immune cells mainly known in the context of allergy, found to play a crucial role in the development of macrophages in the lung.

In recent years the genomes, transcriptomes, and epigenomes of multicellular organisms have been captured in a number of high profile organism-wide atlases. Can proteomics measure up to next-generation sequencing (NGS) technologies when it comes to single cell analysis? Here are the highlights from the Human Proteome Organization (HUPO) World Congress summarizing the latest developments in the field of single cell biology.

Fundamental mechanisms underlying heart development and differentiation have been mapped out, thanks to extensive single-cell transcriptomic analyses.

Unlike most cells in the rest of our body, the DNA (the genome) in each of our brain cells varies from cell to cell, caused by somatic changes. But much remains unknown, including when these changes arise, their size and locations, and whether they are random or regulated. Now, researchers have developed new techniques allowing the detection of CNVs smaller than one million base pairs.

When a fetus develops, everything must be timed to perfection: failures in timing can result in congenital deformities, disabilities, and even death. The big question that developmental biologists have been asking for a long time is this: what sets the pace and the order of developmental events?

Researchers have created a massive database of the changes in gene activity of individual cells in the cerebellum during embryonic development and immediately after birth.