Single-Cell Analysis – News and Features

USC scientists show how progenitor cells that form the kidney’s filtering units mature into entirely different types of cells.

Scientists at Karolinska Institutet in Sweden and University of North Carolina, USA, have identified the cell types underlying schizophrenia in a new study published in Nature Genetics. The findings offer a roadmap for the development of new therapies to target the condition.

A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery.

As part of work recently published in Science Advances, a team of researchers from the Institute of Systems Biology at Yale University has built a microfluidic device to demonstrate that single cells preserve a memory of their mother's dynamic response to glucose limitation stress for multiple generations.

The task of building an entire organism from a single-cell is unbelievably complex, and yet happens across multicellular life. New studies now have traced individual cells' division and growth over the first 24 hours of life in two key organisms.

For the first time, researchers have been able to reconstruct the developmental trajectories of individual embryonic cells.

In the post-genomics era, we look at the powerful new revolution in proteomics. We find out how advances are deepening our understanding of cancer biology and resistance processes, which will lead to new clinical applications such as non-invasive biomarkers and drug development.

Gene expression is the key to why our cells look different, even with identical DNA. Measuring this expression can be a real challenge, but a new computational tool will allow scientists to calculate even the smallest expression levels.

Using single-cell analysis—a technology that allows scientists to track cellular behavior one cell at a time—the team traced the lineage of interneurons from their earliest precursor states to their mature forms in mice.

The Malaria Cell Atlas will allow researchers to identify weak points in the parasite’s lifecycle for intervention with drugs.