Latest On-Demand Webinars & Online Events

An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.

In this webinar, we present a standardized workflow solution, including easy and automated nuclei extraction and isolation for reproducible single-nucleus sequencing analysis.

This presentation will highlight our recent progress in the discovery of N-glycans and phospholipids that significantly contribute to aberrant cancer metabolic pathways in primary tumors and metastases. We have also developed novel MALDI imaging approaches of drugs and drug metabolites that exploit key metabolic differences in tumors.

Join us for an invigorating spatial discussion, where we show the latest data using the PhenoCycler™-Fusion system, the fastest single-cell spatial biology solution.

This inaugural online symposium will explore the tools and techniques being used to study diseases in the lab. Focus will be given to cell culture, organ-on-a-chip and organoid models, as well as, how innovations are enabling researchers to elucidate the underlying biological mechanisms of disease and support diagnostic and therapeutic development.

The novel fragmentation technique, electron activated dissociation (EAD) of the ZenoTOF 7600 system (SCIEX), was employed for peptide mapping of a multispecific monoclonal antibody (mAb) as well as IgG1 and IgG4 mAb samples. A specific focus was put on assessing challenging PTMs, such as glycosylations, amino acid isomers and the localization of a sulfation on a singly charged peptide.

Dr. Nemes will share developments from his lab that enabled the in situ and in vivo measurement of metabolites and proteins in single cells in live tissues and organisms, while Dr. Orsburn will explain how leaps in mass spectrometry can facilitate unprecedented sequence coverage of protein at the single-cell level.

In this webinar you will learn how the power of large-scale proteomics can be leveraged for multiple divergent applications in the field of oncology.

These technologies can help identify new strategies to enhance myocardial repair and regeneration through target validation and manipulation.

The Problem
Manual buffer exchange methods take up tons of your precious time and are a pain to manage in large numbers - often leaving you with inconsistent results and playing catch up to meet your deadlines.

The Solution
Big Tuna is a fully automated buffer exchange platform that can exchange and concentrate up to 96 samples in parallel – with just 30 minutes of setup. By automating the previously painful and error prone process of buffer exchange and concentration, Big Tuna gives researchers the consistent sample handling, degrees of process control and throughput that just aren’t possible with manual methods.

The Proof
Tune in to learn how Big Tuna has helped tons of labs and CDMOs smash their buffer exchange bottlenecks for proteins, mAbs, nucleic acids, AAVs and LNPs. We will show formulation case studies for both mAbs and AAVs that will showcase the type of real recovery results of <96% you can expect from automating your buffer exchange with Big Tuna.