Mass spectrometry (MS)-based omics technologies have revolutionized our understanding of molecular changes in organisms and are crucial for studying metabolism and related diseases through lipidomics and metabolomics. Despite significant advances, there is still a need for robust analytical methodologies in data acquisition, data processing and annotation.
This webinar will demonstrate how LC-Zeno SWATH DIA outperforms conventional DDA in annotating metabolites and lipids in the model organism Gammarus fossarum. Additionally, the presentation will showcase the effectiveness of electron activated dissociation (EAD) in characterizing lipid species and elucidating metabolite isomers. Finally, the webinar will illustrate how EAD and high-resolution targeted approaches improve structural elucidation and molecular network construction.

As proteomics platforms have advanced, the number of proteins measured and sample throughput have dramatically increased. However, have sacrifices or trade-offs been necessary to make these gains?

The liver is a very good example of how tissue architecture can influence aging. Composed mainly of hepatocytes, the position of these cells is key to their role and determines changes in their metabolism and aging profile.

Researchers from the Max Planck Institute have conducted an in-depth multiomics analysis of functional and healthy hepatocytes, characterizing transcriptional, epigenetic, lipidomic and functional signatures to understand the effects of aging.

In this webinar, you’ll hear all about their research, including the novel perfusion technology for resected mouse liver that makes it easy and convenient to obtain viable hepatocytes to analyze.

Immune cell activation, differentiation and function are metabolically demanding processes, and it has now become clear that nutrient access and metabolism play a major role in regulating lymphocyte fate and function. These axes of regulation are crucially important in shaping the immune system when it is activating in metabolically demanding environments, such as tumor tissue. Indeed, the immune response to cancer is characterized by several metabolic defects. In this webinar, Dr. Delgoffe will discuss some of these metabolic insufficiencies within the T cell compartment of solid tumors and reveal novel insights into how these metabolic nodes may be modulated to improve the immune response to cancer.

Join expert speakers, Dr. Christopher Mason of Weill Cornell Medicine, and Dr. Michael Roberts of Auburn University, for an enlightening discussion on the profound impacts of spaceflight on human biology and the unique molecular signatures of aging influenced by resistance training.

In this webinar, you’ll hear from Christof Lenz, PhD, about the importance of analyzing tissue samples in biomedical proteomics, particularly for understanding the molecular basis of cardiac diseases. Our second speaker, Greg Potts, PhD, will showcase how chemoproteomics, in combination with data-independent acquisition, speeds up drug discovery.