We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Advertisement

Development of a Sensitive SWATH™ MS Workflow To Advance the Characterization of CAR T-Cell Therapies

Webinar

 
Development of a Sensitive SWATH™ MS Workflow To Advance the Characterization of CAR T-Cell Therapies
 

Who's speaking at this Webinar?

Dr Camille Lombard-Banek
NCR Postdoctoral Fellow, NIST/IBBR, John Schiel
 

CAR T-cell therapies are emerging anti-cancer treatments, whereby the patient’s immune cells are engineered to express chimeric antigen receptors (CARs) on their surface. Wider adoption of this therapeutic modality would benefit from innovative technologies that can improve the characterization of raw material quality attributes (MQA) and final product quality attributes (PQA).

Here, we present the development of a sensitive proteomic method to characterize CAR T cells using SWATH™ technology. We evaluated key steps of the data acquisition, from separation to detection, to enhance the sensitivity by data dependent and independent methods.

The data represent an instrument benchmarking that will ultimately be used as performance qualification metrics to assure instrument control for biologically relevant decision making of CAR T proteomic samples.

By attending this webinar, you will learn:

  • Strategies on method development for sensitive proteomic analysis
  • Development of MS-based proteomics with SWATH™ MS technology for adoptive cell therapy analysis
  • Implementation of benchmarking and control strategies for reproducible proteomic analysis

 
 
 
Advertisement
 

Like what you just read? You can find similar content on the communities below.

Applied Sciences Cancer Research

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE