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Virus Cells - Microscope Slide Cyprotex Webinar

Drugging the Gut Microflora To Reduce Drug Toxicity


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Gut bacteria can influence how drugs are metabolized, potentially releasing toxic compounds into the gut. 

This webinar will explore the role of gut bacterial β-glucuronidase (GUS) in drug metabolism.

Our expert speaker, Anna Kerins, will dive into how inhibiting GUS enzymes can reduce gut toxicity, improving patient outcomes and allowing for higher, more effective doses.

She’ll outline how in vitro and in vivo studies on two GUS inhibitors demonstrated their ability to prevent gut damage while undergoing metabolism in human, mouse and rat microsomes, opening avenues for the development of gut-targeted GUS inhibitors with unique metabolic pathways. 

Attend this webinar to:
  • Understand the impact of GUS on drug metabolism and toxicity.
  • Explore the role of GUS inhibitors in reducing drug-induced gut damage, particularly with irinotecan.
  • Learn about the in vitro and in vivo metabolism of two GUS inhibitors.
  • Recognize the importance of species differences in drug metabolism and their implications for drug development.
Speaker
A picture of Anna Kerins
Anna Kerins
Principal Scientist
Cyprotex
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