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Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models

An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.

Attend this webinar to:

  • Learn about innovative metabolomics workflows
  • Discover how the Bruker timsTOF Pro and fleX systems can be used in metabolomics workflows
  • Learn how the MALDI-2 post-ionization laser can see never before observed compounds

*For Research Use Only. Not for use in diagnostic procedures.

Gary Patti, PhD
Gary Patti, PhD
Professor, Department of Chemistry, Washington University in St. Louis