We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.

mRNA Snippet

Optimizing mRNA Purification Conditions by Using a High-Throughput Screening Approach

To support the development of mRNA-based therapies scientists require platforms that will help to address the selectivity and capacity requirements for the large-scale manufacturing of mRNA used in vaccine and gene therapy applications.

Typically, mRNA binds to the Oligo dT(25) affinity resin using high ionic strength conditions and neutral pH and is eluted from the column using low ionic strength solutions like water. Although water works well for most mRNA constructs, a need to identify alternative elution buffers which can be used to optimize mRNA recovery, exists.

Watch this 30-minute webinar to discover a resin that enables a simplified mRNA purification workflow and maximizes the removal of the DNA template and other IVT components. 

Watch this webinar to:

  • Learn how to prepare and implement a high-throughput screening approach to identify alternative elution buffer conditions
  • Understand how the ionic strength of the binding conditions can impact the recovery
  • Learn how to apply the optimized purification method towards various lengths of mRNA constructs

For Research Use Only. Not for use in diagnostic procedures.

Brought to you by
Watch this Webinar for FREE Below
Information you provide will be shared with the sponsors for this content. Technology Networks or its sponsors may contact you to offer you content or products based on your interest in this topic. You may opt-out at any time.
Want to invite a colleague?

Click the button below to begin inviting a colleague to this Webinar