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Paired Blind Polytrode and Juxtacellular Recordings In Vivo
Whitepaper

Paired Blind Polytrode and Juxtacellular Recordings In Vivo

Paired Blind Polytrode and Juxtacellular Recordings In Vivo
Whitepaper

Paired Blind Polytrode and Juxtacellular Recordings In Vivo

Paired electrophysiological recordings using more than one electrode in vivo can be challenging. Visual guidance of pipettes can be achieved by combining 2-Photon imaging with the technique. However, this approach is expensive, limited to depths of 1mm and requires that the electrodes fluoresce. In this white paper the authors describe a more cost effective solution. Their approach is to combine computer controllable motorised micromanipulators with trigonometric calculations of the electrode positions in the tissue.


In this white paper, the authors describe a straightforward algorithm  and method to achieve blind ‘paired recordings’ in vivo in a reliable manner, using Scientifica micromanipulators. 

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