Sequencing and microarrays for genome analysis: complementary rather than competing?

The development of genome analysis technologies such as DNA microarrays and next generation sequencing (NGS) has provided the researcher with the unique ability to screen for sequence variants of clinical relevance. Although DNA microarrays and NGS might be viewed as competing platforms, this article examines how exome and targeted sequencing is being implemented in biomedical laboratories and how NGS and microarrays could complement each other to address a range of biological questions.