Glycosylation refers to the formation of linkages with glycosyl groups, covalently attaching a carbohydrate to another molecule. Antibody glycosylation is critical due to the role carbohydrates play in modulating effector functions which affect safety and efficacy of therapeutic antibodies.

Fragment analysis of nucleic acids is an essential, well-known molecular biology tool used in many different research areas. Applications such as cloning, gene editing and fragment length analysis rely on quality control checks to assess the nucleic acid size at the beginning or middle of the workflow to ensure successful end results.

As LC methods are moved from the “transferring” to the “receiving” system, scientists are required to navigate multiple variables resulting from instrument settings or vendor configuration that directly impede method transferability.

The high resolution and scale that single cell analysis provides is revolutionizing drug discovery and development by introducing comparative, longitudinal and causal information that transforms our ability to understand biology and disease.

Download this app note to discover how to distinguish tumor versus normal cells in a heterogeneous sample, reconstruct cell type–specific gene regulatory network
and confirm PAX5 as a critical regulator specific to tumor B cells.

Download this compendium to discover tips and tricks for ultrafiltration including how to desalt samples, concentrate samples and recover low-concentrated samples.

Studying tissue and organ biology is challenging, particularly in mammals, given sample accessibility and ethical concerns. However, the use of organoids alleviates these challenges, supporting researchers in exploring questions that previously could not have been investigated without them.

Download this app note to discover immunoassay platforms that are consistent for your cell therapy and immunology development needs.

While the complexity of organoids remains challenging, technological advances are enabling organoids to be developed and monitored in an automated fashion, so that they can be exploited in high-throughput drug screening assays.

With the advances in 3D culture, liver spheroids made from primary human hepatocytes have been demonstrated to be a useful novel tool for in vitro hepatotoxicity studies.