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Latest App Notes & Case Studies

App Note / Case Study

Rapid Phosphoproteomics With Dia-PASEF

Data-independent acquisition (DIA) has been shown to increase the quantitative reproducibility and accuracy of MS-based phosphoproteomics. This app note explores the impact of dia-PASEF on the speed and sensitivity of phosphoproteomics.
App Note / Case Study

A Novel Method To Assess Sequence Integrity for RNA Therapeutics

RNA-based therapies can modulate cells in a controlled and targeted manner, effectively acting as gene therapies. But, as with any therapeutic, RNA therapeutics must undergo strict quality control (QC) to ensure the product is exactly as specified, with no errors or alternate products.
App Note / Case Study

Superior Characterization of Biotherapeutic Quality Attributes Using Electron Activated Dissociation

The multi-attribute method (MAM) is a powerful LC-MS method that overcomes this challenge by simultaneously monitoring and quantifying multiple PQAs in a single injection.
App Note / Case Study

Simple and Fast-Tracking of Drug Antibody Ratio Distribution

Antibody drug conjugates (ADCs) are biotherapeutics, composed of small molecule drugs conjugated to an antibody scaffold, that have very complex molecular structures.
App Note / Case Study

ICP-MS Analysis of Elemental Impurities in Pharmaceutical Products

Elemental impurities contained in pharmaceutical products are getting more and more attention due to their harmful potential on patient health and impact on drug shelf life and efficacy. ICP-MS is an elemental analysis technology capable of detecting most of these threats at as little as a nanogram level per liter.
App Note / Case Study

Advanced Flow Cytometry for Cell Line Development

Traditional methods are often low throughput, time-consuming and lack linearity. However, advanced flow cytometry has emerged as a more efficient alternative for biologics development.
App Note / Case Study

Maximize Your Long-Read Sequencing Results

Routine, robust methods for long-read sequencing have the potential to allow researchers to analyze long stretches of DNA without the requirement of preamplification and can also enable analysis of complex regions that are otherwise difficult to map.
App Note / Case Study

Automated Parallel Capillary Electrophoresis for Purity Analysis of ssDNA and RNA Oligonucleotides

As oligonucleotides (oligos) are synthesized, small amounts of impurities can be introduced at each step, and different synthesis methods and purification efficiencies can impact the quality of the sample.
App Note / Case Study

An Integrated Multiomic Approach for the Diagnosis of Metabolic Diseases

Inherited metabolic disorders (IMDs) are a vast and complex group of rare genetic diseases presenting throughout a patient’s life span.
App Note / Case Study

A Fully Integrated Spatial Biology Analysis Solution

Extracting biological insights from spatial data is vital to advancing science, however, the analysis of spatial multiomics data is only possible with a robust and scalable informatics solution.
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