Latest App Notes & Case Studies

This application note demonstrates the successful identification of two low-abundance monoclonal antibodies using next-generation protein sequencing.

Oligonucleotides play a crucial role in modern drug development, therefore their accurate characterization is essential. However, given the sheer complexity and diversity of the types of oligonucleotides that are in clinical development, a range of diverse analytical approaches are necessary.

This application note compares the use of pulsed- and constant-field technologies to support researchers in choosing the most suitable automated instrument for their sequencing workflow.

This technical overview highlights the latest fragment analysis and electrophoresis solutions for adapter dimer detection. It explores how greater detection and resolution capabilities can support sequencing efficiency and quality control (QC).

This application note highlights how combined machine learning and FTIR technology can enhance the overall efficiency of your analytical workflow.

This case study highlights the process DuPont, a multinational chemicals company, went through to select a LIMS provider and the significant benefits they experienced as a result.

Mass spectrometry is regarded as the gold standard for protein identification; however, this technique cannot easily discriminate between protein variants and is not accessible to everyday scientists due to the high cost, space and expertise required.

Immunogenicity is a key consideration in the development of safe gene therapy products. In fact, certain product components can cause unintended immune responses with life-threatening implications if not addressed.

This application focus presents the exciting technology behind advances in DIA and discusses how it can be used to enhance research.

Monoclonal antibody (mAb)–based therapeutics have been very successful in treating various diseases, including cancer. The manufacturing of these therapeutic antibodies is a complex operation with low levels of aggregates being a critical quality attribute of the final product, as this will impact the biological activity.