Latest App Notes & Case Studies
App Note / Case Study
An LC-MS/MS Toxicology Workflow for Screening Drugs
One of the major challenges faced by most toxicology laboratories is analyzing hundreds of drugs of abuse in biological samples. This is further complicated by the constantly increasing emergence in the volume of designer and illicit drugs.
App Note / Case Study
A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum
RTP004 is a proprietary peptide used by Revance Therapeutics as a novel excipient in DaxibotulinumtoxinA for injection. Due to its high molecular weight, high isoelectric point and strong non-specific binding property, the sample preparation and LC-MS method development for this peptide is very challenging.
App Note / Case Study
Microflow Chromatography: A Key to More Sensitive Metabolite Identification
In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.
App Note / Case Study
Preclinical Quantification of Trastuzumab in Rat Plasma
In quantifying therapeutic peptides and proteins in biological matrices, traditional ELISA-only based techniques can suffer from high variability, narrow dynamic range, problems with selectivity and typically cannot use internal standards.
App Note / Case Study
Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis
Sample preparation and alternative chromatography techniques are often used to meet the sensitivity needs required in routine bioanalytical assays, but these methods can be time consuming.
App Note / Case Study
Cyclic Peptide Quantitation in Human Plasma
In biotherapeutic development, decreased drug doses and limited sample volumes require higher quantification sensitivity, while the complexity of biological matrices calls for the need of assay selectivity improvement.
App Note / Case Study
Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry
Demands for improved sensitivity in routine bioanalytical assays continue to increase as drug discovery and development programs focus on more efficacious, lower dosage compounds. Pharma development scientists supporting this work therefore require highly sensitive and selective bioanalytical methods for quantification.
App Note / Case Study
DNA Purity Ratio
Many downstream experiments in molecular biology, such as next-generation sequencing, depend on the use of reasonably pure nucleic acid samples in adequate concentration ranges.
App Note / Case Study
Early Screening of Pancreatic Cancer Immunotherapy Target Candidates
It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.
App Note / Case Study
Accelerating Target Validation for Therapeutics With Engineered Cell Libraries
One approach to develop drugs for infectious diseases involves a comprehensive understanding of human-pathogen protein interactions, as targeting host proteins helps reduce the possibility of drug resistance by creating a more significant evolutionary barrier for the virus.
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