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Latest Application Notes

Application Note

Identifying Genetic Drivers of Innate Immunity Using Custom Targeted CRISPR Screens

Using genome-wide CRISPR knockout screens, followed by focused CRISPR screens, researchers at Boehringer Ingelheim probed the gene-phenotype relationship of human monocyte phagocytosis when the cells were challenged with Staphylococcus aureus.
Application Note

Automated Protein Sample Preparation in Regulated Environments

Download this application focus to learn more about the benefits of automated sample preparation for drug development.
Application Note

Top Five Reasons To Consider Fully-Automated Enzyme Assays

Download this app note to discover reasons why you should consider fully automated enzyme analysis.
Application Note

Contract Manufacturing for a Novel Metabolism-Based Liquid Biopsy

When it comes to cancer, diagnosis often relies on tissue biopsy in conjunction with medical imaging. In addition to sometimes being inconclusive, tissue biopsies are associated with risks, high costs and inconvenience for patients, making them ill-suited for screening or tracking disease progression.
Application Note

An Integrated Multiomic Approach as an Excellent Tool for the Diagnosis of Metabolic Diseases

Download this article to learn about a next-generation sequencing technology that integrates genetic and biochemical testing as well as can efficiently diagnose more than 180 metabolic diseases.
Application Note

Quick and Easy Solution for Plasmid Analysis

Because of this, plasmids ideally suit experimental protocols that include cloning. Inserting a piece of DNA into the linearized plasmid and generating multiple copies of the plasmid allows scientists to study DNA sequences or genes.
Application Note

Gene Modification for Cell Therapy Applications

The clinical success of CAR T-cell therapy has spurred increased interest and investments in the advanced therapeutics industry.
Application Note

Detection and Characterization of Mitochondrial Toxicity

A Customized XF Workflow for Detection and Characterization of Mitochondrial Toxicity

Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury.
Application Note

Benefits of Quality Control in the IVT RNA Workflow

The importance of quality control (QC) in laboratory processes is often overlooked but should be considered an essential part of every procedure.
Application Note

Kinetic Curvature: Assessment of Small Molecule Kinetics and Affinity

Surface plasmon resonance (SPR) is a core technology used in many pharma and biotechnology settings for this purpose, however traditional initial SPR screening of weak affinity compounds using a single fixed concentration injection can present numerous challenges.
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