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Application Notes

 
BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay
Application Note

BMG Labtech

The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.

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DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
Application Note

BMG Labtech

This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.

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Growth of Campylobacter using BMG LABTECH’s FLUOstar Omega equipped with ACU
Application Note

BMG Labtech

Campylobacter are Gram negative microaerophilic organisms which are a common commensal of mammals and birds and are one of the most frequently isolated causative agents of human bacterial enteritis worldwide. Infection in humans is frequently associated with the consumption of under cooked poultry and is generally self limiting though it can in a small number of cases result in severe complications such as Guillain-Barre syndrome.

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Miniaturised Platelet Aggregation Assays using the NOVOstar Microplate Reader
Application Note

BMG Labtech

Platelets are small, anucleate blood cells derived from their precursor cells, megakaryocytes that are vital for haemostasis. Following blood vessel injury, subendothelial collagens are exposed to which platelets adhere. The detailed characterisation of platelet function and underlying regulatory mechanisms is important for the development of new strategies to selectively reduce platelet reactivity and prevent thrombosis.

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mosquito® Crystal for the rapid screening and optimisation of crystallisation conditions of the bacterial periplasmic binding protein, HbpA
Application Note

Trevigen

Glutathione is one of the major antioxidants/redox molecules in most aerobic cells, playing an important role in cell metabolism, differentiation, proliferation, and apoptosis. The reduced form of glutathione (GSH) is required for the detoxification of drugs and reactive compounds of both endogenous and exogenous origin.

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Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability
Application Note

BMG Labtech

The blood fluke Schistosoma is a parasitic trematode that is responsible for more than 200,000 human deaths per year. The state of the art to detect Schistosoma viability involves microscopy and knowledge of parasite morphology. The lack of appropriate methods for quantifying Schistosoma viability blocks the development of new anthelmintics.

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The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
Application Note

BMG Labtech

ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.

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Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
Application Note

BMG Labtech

During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.

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An AlphaScreen® SureFire® Phospho-ERK1/2 Assay Performed on BMG LABTECH’s POLARstar Omega
Application Note

BMG Labtech

G-protein coupled receptors (GPCRs) are a large family of receptors which have a broad involvement in cellular responses affecting many important body functions both in health and disease.

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A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition
Application Note

BMG Labtech

Pgp expression has been linked to the effl ux of chemotherapeutic
drugs in human cancers leading to multidrug resistance. Pgp
activity can also result in low oral absorption and poor brain
penetration. Interaction of drugs with the Pgp may also cause
an increase in toxicity of co-administered compounds.

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