Latest Application Notes
TIMScore With PaSER: Exploiting the CCS-Dimension
Download this app note to discover a solution that boosts the numbers of proteins, peptides and PSMs in complex datasets as well as increases protein sequence coverage substantially.
Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography
A crucial step in any pharmaceutical production is the purification of the product. The purification of oligonucleotides (ONs) can be particularly challenging because of the high similarity of target and impurities.
A Tale of Two End-to-End Targeted Metabolomics Workflows
Download this application focus to learn more about two novel, sensitive, targeted metabolomics solutions.
True High-Throughput Analysis of Transporter Activity Screens
Two key ADME (absorption, distribution, metabolism and excretion) properties used to predict the in -vivo performance of a drug candidate are its ability to permeate a cell membrane and its potential to act as a substrate for transmembrane transporter proteins.
Phosphorylated Peptide Post-Translational Modification Site Localization and Isomer Differentiation
However, PTM site localization and quantification of phosphopeptides by collision induced dissociation MS/MS can be challenging, and phospho-peptides can exhibit a partial neutral loss of the phospho group.
Label-Free, Real-Time Live Cell Assays for 3D Organoids
To successfully use these models across a variety of research disciplines and applications, approaches that reduce variability and technology pipelines to image and quantify these complex cell models are required.
Novel Aggregation-Specific Fluorogen Monitors Prefibrillar Protein Aggregation by Fluorescence Polarization
Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative for example Alzheimer’s and Parkinson’s. The transition from soluble, functional protein to insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species.
Cell Viability Assays - Which One Is Best Suited for My Application?
Download this app note to discover a microplate reader that covers a broad range of cell viability assay readouts, provides high sensitivity and full flexibility and offers a fast and easy assay setup.
Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO
Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.
Genomic DNA Extractions Compared With the Agilent Femto Pulse System
Large-insert libraries require specific quality conditions of the starting genomic DNA (gDNA) material for successful outcomes. Physical, enzymatic and chemical shearing of gDNA into smaller fragments can occur at many different points during extraction and handling of gDNA.