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Latest Application Notes

Application Note

TIMScore With PaSER: Exploiting the CCS-Dimension

Download this app note to discover a solution that boosts the numbers of proteins, peptides and PSMs in complex datasets as well as increases protein sequence coverage substantially.
Application Note

Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography

A crucial step in any pharmaceutical production is the purification of the product. The purification of oligonucleotides (ONs) can be particularly challenging because of the high similarity of target and impurities.
Application Note

A Tale of Two End-to-End Targeted Metabolomics Workflows

Download this application focus to learn more about two novel, sensitive, targeted metabolomics solutions.
Application Note

True High-Throughput Analysis of Transporter Activity Screens

Two key ADME (absorption, distribution, metabolism and excretion) properties used to predict the in -vivo performance of a drug candidate are its ability to permeate a cell membrane and its potential to act as a substrate for transmembrane transporter proteins.
Application Note

Phosphorylated Peptide Post-Translational Modification Site Localization and Isomer Differentiation

However, PTM site localization and quantification of phosphopeptides by collision induced dissociation MS/MS can be challenging, and phospho-peptides can exhibit a partial neutral loss of the phospho group.
Application Note

Label-Free, Real-Time Live Cell Assays for 3D Organoids

To successfully use these models across a variety of research disciplines and applications, approaches that reduce variability and technology pipelines to image and quantify these complex cell models are required.
Application Note

Novel Aggregation-Specific Fluorogen Monitors Prefibrillar Protein Aggregation by Fluorescence Polarization

Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative for example Alzheimer’s and Parkinson’s. The transition from soluble, functional protein to insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species.
Application Note

Cell Viability Assays - Which One Is Best Suited for My Application?

Download this app note to discover a microplate reader that covers a broad range of cell viability assay readouts, provides high sensitivity and full flexibility and offers a fast and easy assay setup.
Application Note

Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO

Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.
Application Note

Genomic DNA Extractions Compared With the Agilent Femto Pulse System

Large-insert libraries require specific quality conditions of the starting genomic DNA (gDNA) material for successful outcomes. Physical, enzymatic and chemical shearing of gDNA into smaller fragments can occur at many different points during extraction and handling of gDNA.
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