Latest App Notes & Case Studies

CRISPR/Cas9 gene editing can result in off-target cleavage events, impacting the validity of your final results. Cleavage of unintended targets can cause impaired cell function, cell death or misleading conclusions. CIRCLE-seq is a sensitive in vitro assay that was developed to overcome the challenges associated with off-target screening.

Energy metabolism plays a central role in a wide variety of cellular and physiological processes. Therefore, a deep understanding of how disruption to energy metabolism impacts cells can help in therapeutic drug discovery and development.

Download this app note to discover a method of recombinant protein expression that enables correct protein folding and post translational modification, is suitable for high-density cell culture, and can produce both secreted and intracellular proteins of various species.

Find out how scientists determined which of five extraction methods was optimal for use in a long-read sequencing workflow by comparing the sample quality, sample size and sequencing results.

Download this app note to discover a SWATH DIA workflow that:
Has the speed and sensitivity to acquire high-quality, high-resolution MS/MS data
Reduces the need to generate experimental libraries
Was used to identify 2-fold more proteins than a DDA workflow

From vaccines to gene therapies, RNA produced by in vitro transcription (IVT) has many therapeutic applications.

Need a routine analytical technique that can provide protein expression profiling and targeted drug imaging? MALDI Imaging is used to determine the spatial distribution of molecules in a tissue section, for more complete multiomic information.

Single cell and spatial technologies that profile gene expression across whole tissues are revolutionizing the resolution of molecular states in clinical tissue samples.

One method of analysis commonly used to ensure drinking water quality is the measurement of volatile organic compounds (VOCs). These compounds can appear in drinking water by contamination from numerous sources, including industrial and commercial operations.

There is currently no effective cure or treatment to slow down or stop the progression of Huntington's disease (HD). One reason for this is the lack of accurate and easy-to-use HD models.