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Latest App Notes & Case Studies

Female scientist placing sample tubes into an automated lab analyzer in a modern laboratory.
App Note / Case Study

Streamline High-Throughput Oligonucleotide Analysis With Ion-Pairing-Free Methods

This application note demonstrates how an ammonium bicarbonate-based approach eliminates bottlenecks while maintaining excellent chromatographic performance and mass spectrometry sensitivity.
Abstract glowing orange DNA double helix with connected nodes on a dark network background
App Note / Case Study

Optimize Oligonucleotide Analysis With Advanced Chromatography Methods

This application note reveals how hydrophilic interaction chromatography (HILIC) provides a versatile, MS-compatible alternative that delivers superior separation performance without the limitations of conventional approaches.
High-throughput screening of the compound collection across europe
App Note / Case Study

Why Automation Is Integral to the EU-OPENSCREEN Compound Collection

This case study highlights how EU-OPENSCREEN implemented a fully automated workflow for compound dissolution, aliquoting, storage and plate reformatting, meeting the scale and speed of modern screening demands.
Case study document showing lab technicians and equipment used for automating NGS-based HLA typing for stem cell transplantations
App Note / Case Study

Optimizing Donor Matching With Automated HLA Typing

This case study explores how a leading institution in histocompatibility implemented an automated NGS-based workflow for high-resolution HLA typing.
Front cover of a Cytiva and Nuclera application note on accelerated kinase drug discovery workflow.
App Note / Case Study

Speed Up Kinase Drug Target Characterization

This application note presents a next-generation approach to drug discovery - combining AI-guided structural design with rapid, automated digital microfluidics-based screening workflows that optimize protein expression. Researchers can obtain purifi
Close-up of dried blood spots on filter paper within printed collection circles for analysis.
App Note / Case Study

Trace-Level Detection of Nitazenes in Dried Blood Spot Samples

This application note highlights a complete extraction-to-analysis method that offers the exceptional sensitivity and robust quantitation needed to analyze nine nitazene analogs and brorphine in DBS samples.
Doctor holding a glowing capsule symbolizing AI-driven drug discovery and molecular innovation
App Note / Case Study

AI-Driven Therapeutic Antibody Design

This application note explores how researchers successfully combined AI with advanced multiplexed gene synthesis to design and validate novel single-domain antibodies with atomic-level precision.
Twist Bioscience and IntegraGen application note detailing NGS liquid biopsy solution for MRD detection with graphs and methodology
App Note / Case Study

Advanced MRD Detection Using Liquid Biopsy

This application note outlines a comprehensive workflow for MRD detection, using a next-generation sequencing (NGS) approach to enable ultra-sensitive analysis with unmatched precision.

Refeyn application note on forced antibody degradation using automated mass photometry, featuring sample data graph and descriptive text
App Note / Case Study

Mass Photometry in a Forced Antibody Degradation Study

In this application note, discover how mass photometry can be used to analyze the fragmentation and aggregation of therapeutic antibodies in response to stressors like light, pH variations, and peroxide exposure.
Cover of a Refeyn technical note on antibody aggregation analysis using mass photometry as a column-free method orthogonal to SEC-UV, featuring blue antibody structures on a dark background
App Note / Case Study

Mass Photometry, a Column-Free Orthogonal to SEC-UV

In this technical note, we explore datasets captured through mass photometry and size exclusion chromatography (SEC), comparing how they characterize the aggregation levels in different biosimilar antibodies
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