Latest App Notes & Case Studies

SignalChem Biotech, now part of Sino Biological, boasts one of the largest selections of active enzymes. Leveraging this extensive collection, we offer compound selectivity profiling services to determine the inhibitory profiles and mechanisms of action of drug candidates.

Kinases are a family of enzymes crucial in cell signaling, phosphorylating substrates to regulate various biological processes. Deregulation of kinases can lead to diseases like cancer and cardiovascular disease.

SignalChem Biotech’s team of scientists specializes in crafting active signaling proteins, including kinases, phosphatases, and enzyme substrates. SignalChem Biotech Bio products are extensively used in high-throughput screenings, activity assays, binding assays, cell-based assays, protein interaction studies, and structural analyses.

This application note describes how argon gas dilution (AGD) enhances laboratory productivity and instrument longevity.

This app note highlights the use of magnetic beads with fully automated size selection protocols for reproducible PCR product purification and DNA size selection.

This info kit highlights a rapid detection kit for the sensitive and reliable detection of mycoplasma in biological products.

This study aims to assess the benefits of migrating and modernizing reversed-phase liquid chromatography (RPLC) methods with the Alliance iS Bio HPLC System with test cases of insulin analogs and glucagon-like peptide (GLP-1) drug substances.

In this application note, we’ll assess the benefits of the Alliance iS Bio HPLC System by migrating and modernizing a compendial SEC method outlined in the United States Pharmacopeia (USP) General Chapter <129>.

In this study, we evaluate the Alliance iS Bio HPLC System in a routine QC testing environment for biopharmaceuticals.

This example will demonstrate the ease and added compliance provided in using embedded software tools in the replication or transfer of an existing method to the Alliance iS HPLC System.