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Latest App Notes & Case Studies

Deploying the Alliance™ iS Bio HPLC System as a Modern HPLC for Biopharmaceutical Analysis in QC Environments
App Note / Case Study

Deploying the Alliance™ iS Bio HPLC System as a Modern HPLC for Biopharmaceutical Analysis in QC Environments

In this study, we evaluate the Alliance iS Bio HPLC System in a routine QC testing environment for biopharmaceuticals.
Tools to Assist in Moving Established Methods from an Originator HPLC System to an Alliance™ iS HPLC System
App Note / Case Study

Tools to Assist in Moving Established Methods from an Originator HPLC System to an Alliance™ iS HPLC System

This example will demonstrate the ease and added compliance provided in using embedded software tools in the replication or transfer of an existing method to the Alliance iS HPLC System.
Global Cross Lab Method Transfer of a USP Impurities Method on the Alliance™ iS HPLC System
App Note / Case Study

Global Cross Lab Method Transfer of a USP Impurities Method on the Alliance™ iS HPLC System

In this application note, a global interlaboratory method transfer of a USP organic impurities method was conducted across eight sites with the Alliance iS HPLC System.
HPLC Analysis of Ashwagandha Supplements Using Alliance™ iS HPLC System
App Note / Case Study

HPLC Analysis of Ashwagandha Supplements Using Alliance™ iS HPLC System

This study demonstrates the use of AOAC 2015.17 for the analysis of ashwagandha root extracts and dietary supplements using the Alliance iS HPLC System.
Scaling and Migration of a Hydrophilic Interaction Liquid Chromatography (HILIC) Method for Related Compounds of Ribavirin to Modern HPLC Systems
App Note / Case Study

Scaling and Migration of a Hydrophilic Interaction Liquid Chromatography (HILIC) Method for Related Compounds of Ribavirin to Modern HPLC Systems

In this work, a HILIC method for the analysis of active pharmaceutical ingredient (API), ribavirin, and related compounds was scaled from a 1.7 μm (2.1 x 50 mm) column to 2.5 μm (3.0 x 75 mm), and 3.5 μm (4.6 x 100 mm) columns with equivalent chemistry.
High Utilization and Robustness of the Alliance™ iS HPLC System Using the Analysis of a USP Impurity Method
App Note / Case Study

High Utilization and Robustness of the Alliance™ iS HPLC System Using the Analysis of a USP Impurity Method

In this application note, we will demonstrate how the Alliance iS HPLC System operated over forty days with consistent, accurate results of the USP Fluconazole Organic Impurities method.
Method Migration of a Normal Phase HPLC Method for Tocopherols in Dietary Supplements
App Note / Case Study

Method Migration of a Normal Phase HPLC Method for Tocopherols in Dietary Supplements

This work describes the migration of a method from legacy HPLC systems to the modern Alliance™ iS HPLC System.
HPLC Analysis of Soft Drinks Using Alliance™ iS HPLC System
App Note / Case Study

HPLC Analysis of Soft Drinks Using Alliance™ iS HPLC System

This study demonstrates using a previously reported HPLC method for the analysis of using the Alliance iS HPLC System. The method uses a preformulated mobile phase, wash solvent, and standards from Waters™ (Waters Beverage Analysis Kit).
Replicating an HPLC Method for Water-Soluble Vitamins on the Alliance™ iS HPLC System
App Note / Case Study

Replicating an HPLC Method for Water-Soluble Vitamins on the Alliance™ iS HPLC System

Here, we will demonstrate the ability to achieve the same quantitative results on legacy and newer HPLC systems. The legacy Alliance e2695 System and the Alliance iS HPLC System were chosen for method migration
Analysis of Azithromycin on the Alliance™ iS HPLC System: System Performance under Challenging Method Conditions
App Note / Case Study

Analysis of Azithromycin on the Alliance™ iS HPLC System: System Performance Under Challenging Method Conditions

This application note will discuss the challenges of this method and compare the results obtained across a number of different HPLC systems.
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