Latest App Notes & Case Studies

App Note / Case Study
Deploying the Alliance™ iS Bio HPLC System as a Modern HPLC for Biopharmaceutical Analysis in QC Environments
In this study, we evaluate the Alliance iS Bio HPLC System in a routine QC testing environment for biopharmaceuticals.

App Note / Case Study
Tools to Assist in Moving Established Methods from an Originator HPLC System to an Alliance™ iS HPLC System
This example will demonstrate the ease and added compliance provided in using embedded software tools in the replication or transfer of an existing method to the Alliance iS HPLC System.

App Note / Case Study
Global Cross Lab Method Transfer of a USP Impurities Method on the Alliance™ iS HPLC System
In this application note, a global interlaboratory method transfer of a USP organic impurities method was conducted across eight sites with the Alliance iS HPLC System.

App Note / Case Study
HPLC Analysis of Ashwagandha Supplements Using Alliance™ iS HPLC System
This study demonstrates the use of AOAC 2015.17 for the analysis of ashwagandha root extracts and dietary supplements using the Alliance iS HPLC System.

App Note / Case Study
Scaling and Migration of a Hydrophilic Interaction Liquid Chromatography (HILIC) Method for Related Compounds of Ribavirin to Modern HPLC Systems
In this work, a HILIC method for the analysis of active pharmaceutical ingredient (API), ribavirin, and related compounds was scaled from a 1.7 μm (2.1 x 50 mm) column to 2.5 μm (3.0 x 75 mm), and 3.5 μm (4.6 x 100 mm) columns with equivalent chemistry.

App Note / Case Study
High Utilization and Robustness of the Alliance™ iS HPLC System Using the Analysis of a USP Impurity Method
In this application note, we will demonstrate how the Alliance iS HPLC System operated over forty days with consistent, accurate results of the USP Fluconazole Organic Impurities method.

App Note / Case Study
Method Migration of a Normal Phase HPLC Method for Tocopherols in Dietary Supplements
This work describes the migration of a method from legacy HPLC systems to the modern Alliance™ iS HPLC System.

App Note / Case Study
HPLC Analysis of Soft Drinks Using Alliance™ iS HPLC System
This study demonstrates using a previously reported HPLC method for the analysis of using the Alliance iS HPLC System. The method uses a preformulated mobile phase, wash solvent, and standards from Waters™ (Waters Beverage Analysis Kit).

App Note / Case Study
Replicating an HPLC Method for Water-Soluble Vitamins on the Alliance™ iS HPLC System
Here, we will demonstrate the ability to achieve the same quantitative results on legacy and newer HPLC systems. The legacy Alliance e2695 System and the Alliance iS HPLC System were chosen for method migration

App Note / Case Study
Analysis of Azithromycin on the Alliance™ iS HPLC System: System Performance Under Challenging Method Conditions
This application note will discuss the challenges of this method and compare the results obtained across a number of different HPLC systems.
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