Latest App Notes & Case Studies
Nephelometric Monitoring Growth of Candida albicans Using BMG LABTECH’s NEPHELOstar
Laser nephelometry has been shown to be a reliable technique for the measurement of drug solubility in 96-well plate format. In this note the use of BMG LABTECH´s NEPHELOstar to investigate the effects of complexation on the drug antimycotic activity is described. Laser nephelometry can distinguish between the concentration at which the drug just goes into or just comes out of solution. This is presented in phase solubility studies. Furthermore nephelometry was used to monitor fungal growth.
New Transcreener® ADP2 FP Assay performed on BMG LABTECH’s PHERAstar Plus HTS Microplate Reader
Transcreener™ ADP2 Assay kits are far-red competitive fluorescence polarization immunoassays based on the detection of ADP. Any enzymatic reaction that uses ATP in a range from 0.1-1000 µM can be monitored. With its dual emission detection and five photomultiplier tubes, BMG LABTECH´s PHERAstar Plus provides the speed and sensitivity needed to take full advantage of BellBrook Labs Transcreener™ technology. Furthermore, a specific optical module was developed, thereby making assay setup simple.
Africa and Design of Experiments
Reaction optimisation work using traditional techniques can be complex, time consuming and expensive, but is a vital part of the development of all chemical processes. One approach is the use of statistical experimental design (DoE). This application note gives some guidance on DoE and it’s use with the Africa system.