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Comprehensive Characterization of O-Linked Glycosylation in Etanercept by Electron Activated Dissociation

Glycosylation is a common post-translational modification (PTM) that plays a critical role in antibody effector functions. Comprehensive characterization of N- and O-linked glycosylation in protein therapeutics is essential for ensuring drug safety and efficacy.

Accurate determination of glycosylation sites using traditional collision-based MS/MS approaches is extremely challenging.

Download this app note to learn how electron activated dissociation can:

  • Preserve the glycan structures in glycopeptide fragments
  • Provide confident identification and accurate localization of O-glycosylation
  • Be leveraged to elucidate complex glycosylation profiles in protein therapeutics