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Detecting Contaminants in Cell-Free DNA for Better Biomarker Discovery

Cell-Free DNA
Credit: iStock

Cell-free DNA (cfDNA) – free circulating DNA fragments released by apoptotic cells – is a useful starting material for downstream genetic analysis. Hence, studying cfDNA can support diagnostic testing and reveal novel biomarkers.

Quality control is essential in cfDNA sequencing workflows to save time, resources and ensure reliable results. However, cfDNA quality assessment is challenged by low sample yield, complex fragmentation patterns and the presence of contaminating high molecular weight (HMW) DNA.

This application note presents the latest electrophoretic solutions for a more rapid and reliable assessment of the total cfDNA sample and optimal biomarker discovery.

Download this application note to discover:

  • Automated electrophoresis workflows for efficient cfDNA fragment analysis
  • How to evaluate the total DNA concentration
  • How to assess cfDNA subcomponents separately from HMW DNA
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