Development of a Homogenous RSV Neutralisation Assay on the Mirrorball Fluorescence Cytometer

Human respiratory syncytial virus (RSV) is a syncytial virus that can cause serious respiratory tract infections, especially in infants and young children[1]. To date there is no licensed vaccine against RSV infection and the only preventative treatment option is the neutralising anitbody palivizumab, which is given to high risk infants by passive administration[2]. Therefore there is a strong drive to identify novel RSV-neutralising antibodies for therapeutic/preventative applications. Here we present the development and implementation of a simple RSV-neutralisation assay on TTP Labtech’s mirrorball fluorescence cytometer.