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Enhancing Precision in RNA-Seq with Target Enrichment

A snippet of a DNA helix being captured
Credit: iStock

Total RNA sequencing (RNA-seq) provides an unbiased view of the transcriptional profile of cell populations. However, most RNA-seq experiments encounter numerous non-informative reads, such as those from highly abundant non-coding RNAs, intronic sequences and contaminating genomic DNA.

Target enrichment concentrates sequencing efforts on specific genomic regions, enhancing the sensitivity for detecting low-abundance transcripts or profiling particular genes of interest.

This application note describes a novel design strategy aimed at reducing bias and facilitating the discovery of novel fusion genes. 

Download this application note to discover:

  • A powerful and targeted approach for profiling transcription
  • Accurate and reproducible quantification of transcripts spanning a wide range of expression levels 
  • Enhanced sequencing efficiency, enabling the capture of RNA fusions common in cancers
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