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Application Note

LC-MS for Detection of SARS-CoV-2 Viral and Host Proteins

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Application Note

LC-MS for Detection of SARS-CoV-2 Viral and Host Proteins

This technical note provides a comprehensive LC-MS proteomic analysis to detect and monitor COVID-19 infection severity and disease progression. An LC-MS assay was developed to quantify targeted peptide surrogates from critical proteins from nasopharyngeal swab and plasma samples obtained from individuals testing positive for SARS-CoV-2 coronavirus using a reverse transcription polymerase chain reaction (RT-PCR) test.

Download this technical note to discover how to:

  • Ensure high confidence in identification and sequencing protein-specific peptides that are moved to targeted methods
  • Establish verification metrics for targeted peptide detection and quantification for infectious disease analysis
  • Understand the importance of determining viral load in assessing health aspects
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