Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo Liquid Handler

The Labcyte Echo 500 series revolutionizes liquid transfer by using acoustic energy to eject fluids. The Echo liquid handler is completely touchless—no tips or nozzles, and no material contacts the sample as it moves from source to destination. Low-volume, accurate and precise transfer at volumes of 2.5 nL and up allow for miniaturization to previously unattainable volumes. Miniaturization reduces protein and reagent consumption in crystallization trials. Dynamic Fluid Analysis™ allows for transfer of proteins and essentially all sparse matrix screens using a single fluid class setting, which eliminates the need for multiple settings or frequent calibrations. Transfer of samples from any well of a source to any destination further minimizes sample consumption and simplifies assay setup and execution.