Viral Genetics and Immune Evasion: Implications for Vaccine Development
Although DNA viruses also undergo genetic changes, this article will focus on the changes seen in RNA viruses, such as human immunodeficiency virus-1 (HIV-1), influenza A virus (IAV) and SARS-CoV-2.
Developing Nanobodies and Antibodies Against SARS-CoV-2
Although the COVID-19 pandemic is unprecedented in scope, researchers have met this challenge by developing a suite of preventive and therapeutic strategies to combat the virus. This article explores the development of nanobody- and antibody-based therapeutics against SARS-CoV-2.
Will UK Public Approval of Whole Genome Sequencing for Newborn Screenings Lead to National Rollout?
There are still a number of critical questions that need to be answered before WGS becomes a staple of neonatal care in the NHS. What are its benefits? What are the costs involved? What potential ethical issues does it incur?
Memories of Cancer: What the Extracellular Matrix Can Tell Us About Cancer and How To Combat It
Chronic inflammation has long been linked to cancer, especially the most lethal and untreatable types. But the details of this mysterious relationship have also long defied scientific elucidation – until now.
COVID-19 Puts Mass Spectrometry in the Spotlight
Studying viruses requires integrating several complementary MS techniques. In this article, we review a range of approaches that can address questions about virus structure and function.
Vaccine Booster Shots
Sachin Rawat explores the concept of vaccine booster shots, how they are manufactured and when their administration is appropriate, with insights from experts in immunology.
Pediatric Drug Development: Key Considerations and Challenges
Pediatric medicines are vital to the health and wellbeing of children. Nevertheless, a core principle in any pediatric drug development program is that “children should not be enrolled in a clinical study unless necessary to achieve an important pediatric public health need”. As such, the balance of risk and likely clinical benefits must be assessed and the child should not be adversely impacted by enrolment in the research study.
Scientific Storytelling: It's All About Context
In this interview, Dr. Yotam Ophir discusses the different types of narratives that exist around science, their impact and why retractions should be interpreted as a positive step in scientific progress.
An Introduction to the Light Microscope, Light Microscopy Techniques and Applications
Today, light microscopy is a core technique in many areas of science and technology. In this article, we explore the basic working principle of light microscopy and discuss some more advanced forms of light microscopy that are commonly used today, comparing their strengths and weaknesses for different applications.
HIV Vaccines: Will mRNA Be a Game Changer?
Will a "new-era" in vaccinology prompted by the COVID-19 pandemic finally solve the biggest biomedical challenge of our generation, the development of a HIV vaccine? Only time, and trials, will tell.
Privacy in the Brain: The Ethics of Neurotechnology
The rise of neurotechnology promises huge advances for people with motor disabilities. But with pioneers of brain implant devices looking to one day roll them out to the wider population, how can we prepare for the moral minefield such technology could become?
This article highlights the adverse impact of microplastics (MPs) on our environment, detection methods for MPs and the challenges in the detection of MPs.