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The Value and Versatility of Clinical Flow Cytometry
ArticleFlow cytometry has inarguable potential as a clinical tool for disease diagnosis, prognosis, and therapeutic monitoring. However, some challenges remain in translating the full promise of FCM into clinical practice. Here, some of the current clinical applications of FCM will be discussed, as well as some of the compelling new applications being researched.
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The Promise of in vitro 3D Organoid Models: Meeting the ADME-Tox Testing Needs of the Pharmaceutical Industry
ArticleFor many years, biologists have relied on in vitro 2-dimensional (2D) cell culture models to perform preclinical ADME-Tox assays. While these models are useful for informing aspects of drug discovery, such as cytotoxicity, they are limited in their translatability to drug metabolism and toxicity in humans. Recently, in vitro 3-dimensional (3D) organoid models that more closely mimic human biological systems show promise in supporting ADME-Tox studies in the early stages of the drug development process, compared to their 2D counterparts.
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Scientists Take Action To Stop Gender Inequality and Sexual Harassment in STEM
ArticleIn December 2018, a diverse group of scientific researchers gathered to challenge a key issue in the science, technology, Engineering and mathematics (STEM) workforce: gender bias, and sexual harassment. Now, the conclusions from the meeting have been eloquently described by 23 authors in an article published in the journal Science.
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Are Psychiatric Diagnoses “Scientifically Meaningless” as Claimed?
ArticleIn this opinion piece, psychiatrist Samei Huda responds to a recent journal article published in Psychiatry Research that labeled psychiatric diagnoses as "scientifically meaningless".
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Nanodiscs: The Mobile Home for Membrane Proteins
ArticleIn this article, we explore the use of nanodiscs for overcoming the challenges associated with studying membrane proteins.
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The Cloud with a Shiny Lining: The Advanced Data Visualization Tools Uncovering Hidden Biopharma Insight
ArticleThe biopharmaceutical industry has access to more information than ever before. This data must be stored, managed and ultimately analyzed efficiently to advance the development of safe and efficacious treatments. In this article, Thermo Fisher Scientific’s Cheryl Moody Bartel explores how new tools are meeting this challenge.
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You’re Unique, So Your Nutrition Should Be Too: An Interview With Professor Tim Spector
ArticleRecent research has shown that modifiable factors, such as our microbiome diversity, have a much more significant effect on many of our responses to food than fixed factors, like age or genetics. To learn more about predicting and modifying responses to food we spoke with Professor Tim Spector, expert on personalized nutrition.
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Chronologically, I'm 23, But Biologically – I'm 26
ArticleIn this article, science writer Molly Campbell explores the growing trend of "epigenetic wellness", and puts her own DNA to the test, courtesy of Chronomics.
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The Fine Cell Line
ArticleCell lines with an extended or “immortal” lifetime exist to avoid having to extract them repeatedly from fresh tissues. While this has undoubtedly propelled forward the use of cell culture within biomedical science, it also comes with drawbacks that are often blissfully or willfully ignored. These drawbacks may have been tolerated so far – but as cellular assays get ever closer to impacting the patient, is it still acceptable to “turn a blind eye”?
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Vitamin B12 Deficiency: What is Pernicious Anaemia, and Why Can it Be so Dangerous?
ArticleAn estimated 6% of people in the US and UK suffer from vitamin B12 deficiency.
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