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Artificial Intelligence, Real Solutions: How AI Can Accelerate Drug Discovery
Article

The rate at which new drugs are discovered is in decline, and computer-aided drug design has not produced the radical change in the success of candidate drugs the pharma industry anticipated. Artificial intelligence (AI)-based approaches are the new hope for revolutionizing the drug discovery process. But are these, as computer-aided drug design was, an over-hyped time bomb waiting to be found out? Or is it truly a revolution on the cusp of realizing its promise?

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Inflamyloid: What Is It and Why Is It Important in Alzheimer's Disease?
Article

Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Classically, the “amyloid” hypothesis, which ties the disease’s spread to that of amyloid protein, is thought to underlie AD’s pathology. After years of mixed to negative results in clinical trials, new research is underway to investigate what role the brain’s own immune system plays in amyloid-driven disease; an “infl-amyloid” hypothesis.

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Exploiting Epigenetics in Cancer Treatment
Article

Changes to the complex of DNA and the proteins that form chromatin are important drivers in many cancers. We explore the challenges and progress in the development of new therapies targeting epigenetic regulators.

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Through the Looking Glass of Single Cell Proteomics
Article

To pick apart the differences between individual cells in complex multicellular organisms, we need to look at cells one-by-one. This article takes a look at how several scientists in North America are using single cell proteomics (SCP) technologies to discern disease pathogenesis and enhance directed stem-cell differentiation.

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Exploring the Public’s Perception of Food Fraud
Article

When you go to the shops to buy the weekly groceries, it’s quite likely you’ll find yourself thinking about where your food has come from. Is this organic? Is that free-range? You are perhaps less likely to find yourself wondering, “Is this food fake?”

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A Faster Way to Quantitatively Profile the Lipidome
Article

The lipidome refers to the totality of lipids in cells. In this article, PREMIER Biosoft's Sanjib Meitei explains how his team developed a new technique that can quantitate and separate lipidome sammples in just 15 minutes.

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Understanding the Lytic Cycle – What Are the Steps?
Article

Bacteriophage (phage) are viruses that specifically infect bacteria. They have a two-phase lifecycle, residing in a dormant state within the host genome (lysogenic cycle) or hijacking the host cellular machinery for their own replication (lytic cycle). Here we will explore the important steps of the lytic cycle.

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Healthcare Interoperability Woes: Three Solutions that Create Optimism
Article

Healthcare interoperability remains an intractable problem; both healthcare providers and patients feel unease about limited access to medical data, which results in lower care quality and poor patient engagement. Although daunting, these challenges aren’t insurmountable. In this feature, we’ll explore what has been and what could be done to foster the creation of an interoperable infrastructure.

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Cold Plasma for Seed, Fruit and Vegetable Decontamination and Plant Disease Control
Article

An effective way to increase crop yield is to minimize losses to pathogenic microorganisms by improving the disease resistance of crop plants. A recently emerging alternative to conventional methods for improving plant disease resistance is cold plasma.

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Unlocking the Secrets of Brain Organization -in the Fruit Fly
Article

As many people spent the summer trying to keep the flies away from their fruit-bowls, an international group of scientists published one of the biggest and most important datasets in the field of connectomics to date, the complete 3D electron micrograph volume of the fruit-fly (Drosophila melanogaster) brain.

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