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The Glycome and Cancer
Article

The surfaces of cancer cells frequently express different types of glycoproteins, and because healthy cells don’t express these molecules (or do so at a much lower level), there has been significant interest in them as potential anticancer targets. Recent advances suggest we are about to see a resurgence in cancer glycomics.

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Scientists Explore the Molecular Mechanics that Drive us to Sleep
Article

Scientists describe how phosphorylation of 80 synaptic proteins drives our sleep/wake cycles

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Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells
Article

Although cisplatin is clinically proven to combat numerous human cancers – bladder, head and neck, lung, ovarian, testicular – resistance to treatment remains a key challenge, and cisplatin patients can often relapse. Having the ability to determine the cellular uptake of cisplatin is key to developing novel strategies to increase tumor cell sensitivity to cisplatin.

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Case Study: Improve your lab’s efficiency and data compliance with a chromatography data system
Article

In this Case Study, Peter Zipfell of Thermo Fisher Scientific explains how Broughton Laboratories, an analytical laboratory that supports method development and validation projects across pharma, implemented and upgraded a chromatography data system (CDS), increasing lab efficiency and improving data verification processes for overall time savings.

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The Gene Factory: Can Enzymes Revolutionize Man-Made DNA Synthesis?
Article

Building artificial DNA sounds like a technology out of science fiction, but has been conducted in labs for nearly 40 years. To make the potential of synthetic DNA a reality, new methods are being developed that aim to make creating DNA as fast as sequencing it.

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We're Not Prepared for the Genetic Revolution That's Coming
Article

New technologies are making genetic information (and the power to manipulate it) more widely available that ever before. What the public do with that information, and the effects of those actions, could be a defining theme of the 21st century.

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The Ionic Basis for Electrosensation In Sharks and Skates
Article

Neuroscientists have identified the ionic basis for electroreception in sharks and their relatives, skates.

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How Are We Developing Vaccines for the Future?
Article

This article highlights the types of vaccine, trends in developing future vaccines and discusses new delivery methods and strategies to help advance our understanding of the immune system.

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Cryo-EM and CX-MS: The Power Couple of Proteomics
Article

An ambitious new workflow has married two cutting-edge proteomic analysis techniques to improve imaging of large protein assemblies. The combination of electron cryo-microscopy (cryo-EM) and cross-linking coupled mass spectrometry (CX-MS) allows deeper interrogation of protein structures to a level of detail that the techniques are incapable of obtaining on their own.

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