Latest Conference Recordings

Imaging Gene Regulation in Living Cells at the Single Molecule Level
Imaging Gene Regulation in Living Cells at the Single Molecule Level

Conference Recording

In this talk, James Zhe Liu presents his teams latest efforts in harnessing a set of advanced super-resolution, single-molecule imaging approaches to study how enhancer-binding pluripotency factors (Sox2/Oct4) dynamically search for and assemble on their cognate sites in live embryonic stem (ES) cells.

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Complex Tissue Models that Mimic the Tumour Microenvironment, Heterogeneity and Invasion of Cancer
Complex Tissue Models that Mimic the Tumour Microenvironment, Heterogeneity and Invasion of Cancer

Conference Recording

In this talk, Matthias Nees discusses the development of cell culture model systems to recapitulate key aspects of cancer progression and to functionally validate biomarkers, target genes, and molecular signaling pathways.

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Single Domain Antibodies: From Conformational Sensors to Bispecific Antibodies for Immunotherapy
Single Domain Antibodies: From Conformational Sensors to Bispecific Antibodies for Immunotherapy

Conference Recording

We are using single domain antibodies as innovative tools such as biosensors able to capture the conformation states of some membrane receptors such as EGFR or metabotropic glutamate receptors (mGluRs) on living cells.

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Bi-specific Redirected T-cell Immunotherapy Targeting P-cadherin Expressing Tumors
Bi-specific Redirected T-cell Immunotherapy Targeting P-cadherin Expressing Tumors

Conference Recording

Lioudmila Tchistiakova, Senior Director, Pfizer Inc, USA, speaking at Antibodies in Drug Discovery.

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High Content Analysis Of Human Pluripotent Stem Cell-Derived Endothelial Cells
High Content Analysis Of Human Pluripotent Stem Cell-Derived Endothelial Cells

Conference Recording

The goal of our project is to better identify and grow the optimal endothelial populations following their generation from human pluripotent stem cell cultures. The production of adequate cells is critical for the success of cell-based drug discovery in ischemic disease.

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Discovery and Manufacturing Strategies for Novel, Homogeneous ADC Molecules
Discovery and Manufacturing Strategies for Novel, Homogeneous ADC Molecules

Conference Recording

Several key learnings have emerged through application of rapid re-iterative ADC design using reactive non-natural amino acids to specifically position conjugation sites: Site-specific homogeneous molecules can improve therapeutic index preclinically and have the potential to optimize clinical impact for a given combination of antibody and warhead. Site matters.

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Biomaterials as Stem Cell Regulators in the Development of in vitro Tissue Models
Biomaterials as Stem Cell Regulators in the Development of in vitro Tissue Models

Conference Recording

An overview on the versatility of polyurethane chemistry and their role as stem cell regulators in the design of scaffolds for regenerative medicine or pharmaceutical, diagnostic investigation to test new therapeutic strategies/drugs or elucidate aspects of cell functionality.

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Decomposing the Sources of Molecular Variation in Human Induced Pluripotent Stem Cells
Decomposing the Sources of Molecular Variation in Human Induced Pluripotent Stem Cells

Conference Recording

Here, we describe the initial analysis of the genomes, epigenomes, transcriptomes and proteomes of IPS lines from healthy individuals generated by HIPSCI.

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OptiLinked FDCs: Fully Armed Antibody Fragment Drug Conjugates
OptiLinked FDCs: Fully Armed Antibody Fragment Drug Conjugates

Conference Recording

Mahendra Deonarain, Antikor Biopharma Ltd, UK discusses Fully-Armed Antibody Fragment Drug Conjugates at Antibodies in Drug Discovery 2016.

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Bringing Biologically Relevant Cells to Life - iPSC Technology in Discovery and Safety Assessment
Bringing Biologically Relevant Cells to Life - iPSC Technology in Discovery and Safety Assessment

Conference Recording

AstraZeneca present data, showing large scale generation of functional pancreatic beta-cells, at a scale commensurate with drug-discovery activities. Furthermore, data is presented demonstrating the power of combining precise genome editing with iPSC technology in target validation.

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